+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The role of the immune response against tissue transglutaminase in the pathogenesis of coeliac disease

The role of the immune response against tissue transglutaminase in the pathogenesis of coeliac disease

Autoimmunity Reviews 3(2): 13-20

The development of autoimmunity to tissue transglutaminase (TGase 2) is a striking feature of coeliac disease, an enteropathy that develops in genetically susceptible individuals upon exposure to dietary gluten. IgA anti-TGase 2 autoantibodies are present in at least 98% of coeliac patients on a gluten-containing diet and provide a valuable tool for the diagnosis of the disorder. During disease development, the formation of TGase 2-gliadin complexes through TGase 2 activity appears to be central for B-cell epitope spreading from gliadin to TGase 2. However, the potential role of an immune response against TGase 2 in the pathogenesis of coeliac disease and for the development of the intestinal lesion remains unclear. Recently, an inhibitory effect of anti-TGase 2 autoantibodies from coeliac patients on TGase 2 activity in vitro has been described. Here, we report that a cellular and humoral response against TGase 2 can be induced in TGase 2 (-/-) and wildtype mice on a C57BL/6 background by s.c. immunization with human recombinant or guinea pig TGase 2 in complete Freund's adjuvant. Immunized wildtype, but not TGase 2 (-/-) mice develop periductal lymphocytic infiltrates in lacrimal glands. Although no intestinal lesions were found, this observation lends support to the concept that the development of autoimmunity against TGase 2 is a pathological event that might ultimately lead to organ damage.

(PDF emailed within 0-6 h: $19.90)

Accession: 035931331

Download citation: RISBibTeXText

PMID: 15003183

DOI: 10.1016/s1568-9972(03)00054-5

Related references

Tissue transglutaminase treatment leads to concentration-dependent changes in dendritic cell phenotype--implications for the role of transglutaminase in coeliac disease. Bmc Immunology 13: 20, 2012

A role for anti-transglutaminase 2 autoantibodies in the pathogenesis of coeliac disease?. Amino Acids 36(4): 685-691, 2008

Tissue transglutaminase and coeliac disease pathogenesis: Potential molecular mechanisms for other human diseases. Neurochemistry International 40(1): 79-83, 2002

Anti-tissue transglutaminase antibodies in coeliac disease are not a response to gut damage alone. European Journal of Gastroenterology and Hepatology 16(5): 471-473, 2004

Anti-tissue transglutaminase antibodies and their role in the investigation of coeliac disease. Annals of Clinical Biochemistry 43(Pt 2): 105-117, 2006

Is the search for serum antibodies to gliadin, endomysium and tissue transglutaminase meaningful in psoriatic patients? Relationship between the pathogenesis of psoriasis and coeliac disease. British Journal of Dermatology 147(1): 187-188, 2002

Are positive serum-IgA-tissue-transglutaminase antibodies enough to diagnose coeliac disease without a small bowel biopsy? Post-test probability of coeliac disease. Journal of Crohn's and Colitis 6(8): 861-866, 2012

Human tissue transglutaminase enzyme linked immunosorbent assay outperforms both the guinea pig based tissue transglutaminase assay and anti-endomysium antibodies when screening for coeliac disease. European Journal of Pediatrics 161(5): 284-287, 2002

Role of tissue transglutaminase in gliadin binding to reticular extracellular matrix and relation to coeliac disease autoantibodies. Autoimmunity 28(4): 185-195, 1999

Role of Tissue Transglutaminase in Gliadin Binding to Reticular Extracellular Matrix and Relation to Coeliac Disease Autoantibodies. Autoimmunity 28(4): 185-195, 1998

Quality not quantity for transglutaminase antibody 2: the performance of an endomysial and tissue transglutaminase test in screening coeliac disease remains stable over time. Clinical and Experimental Immunology 171(1): 100-106, 2013

Transglutaminase and the pathogenesis of coeliac disease. European Journal of Internal Medicine 19(2): 83-91, 2008

Role of human-tissue transglutaminase IgG and anti-gliadin IgG antibodies in the diagnosis of coeliac disease in patients with selective immunoglobulin A deficiency. Digestive and Liver Disease 36(11): 730-734, 2004

Tissue transglutaminase as the autoantigen of coeliac disease. Gut 41(4): 565-566, 1997

Tissue transglutaminase A useful test for coeliac disease?. Gut 46(11): A48, 2000