+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Thermogenic responses to cold acclimation in naked mole-rats; evidence for central constraints limiting metabolism

Thermogenic responses to cold acclimation in naked mole-rats; evidence for central constraints limiting metabolism

American Zoologist 41(6): 1400-1401

Naked mole-rats (Heterocephalus glaber) are hairless rodents that exhibit an unusual endothermic yet poikilothermic mode of thermoregulation. We questioned why this may be the case and how these animals respond to cold acclimation (CA). Specifically we asked if central or peripheral constraints influenced their mode of thermoregulation and whether or not thermogenic capacity and activity would be augmented with CA. Animals were housed at either 30degreeC (Control) or at 25degreeC (CA). These ambient temperatures (Tas) were specifically chosen, for when naked mole-rats are housed at 30degreeC, resting metabolic rate (RMR) peaks at 25degreeC and is four times greater than that at 30degreeC. This response to acute changes in Ta induces a greater response than shown by mice at 5degreeC. We measured changes in responses to acute Tas, as well as norepinephrine (NE) induced non-shivering thermogenesis and biochemical changes in brown adipose tissue mitochondrial activity and capacity. CA did not elicit an increase in NST capacity. Similarly GDP binding was unaltered. Mitochondrial proton conductance, an indicator of BAT thermogenic activity was however enhanced in the CA group and corresponded to the 50% increase in BMR and elevated thyroxine concentrations. Unchanged thermoregulatory capacity together with the high NST responses regardless of Ta, imply that thermogenesis in naked mole-rats is maximally primed and that it must be constrained by central limits, presumably to the oxygen delivery and transport systems.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 035948990

Download citation: RISBibTeXText

Related references

Unchanged survival of renal transplants in patients with a mutated chemokine receptor 5. Journal of the American Society of Nephrology 10(PROGRAM AND ABSTR ISSUE): 701A, 1999

Brown adipose tissue thermogenesis is activated by electrical and chemical l glutamate stimulation of the ventromedial hypothalamic nucleus in cold acclimated rats. Brain Research 522(1): 76-82, 1990

Thermogenic capacity and expression of uncoupling protein gene of brown adipose tissue from Mongolian gerbils (Meriones unguiculatus) during cold acclimation. Acta Zoologica Sinica 47(4): 388-393, 2001

Evidence for contemporary plant mitoviruses. Virology 518: 14-24, 2018

Shivering and its cost during reproductive behaviour in neotropical owl butterflies, Caligo and Opsiphanes (Nymphalidae: Brassolinae). Animal Behaviour 47(1): 23-32, 1994

Investigation of nucleotide binding sites on chloroplast coupling factor 1 with 3 o 4 benzoylbenzoyl atp. Proceedings Of The National Academy Of Sciences Of The United States Of America: -1953, 1985

Investigation of nucleating lysozyme solutions. Acta Crystallographica. Section D Biological Crystallography 50(Pt 4): 396-397, 1994

Telemonitoring: use in the management of hypertension. Vascular Health and Risk Management 10: 217-224, 2014

Peritoneal Protein Clearance Is a Function of Local Inflammation and Membrane Area Whereas Systemic Inflammation and Comorbidity Predict Survival of Incident Peritoneal Dialysis Patients. Frontiers in Physiology 10: 105, 2019

Neoteny in a lamprey. Nature 179(4566): 925-926, 1957

Prolonged local anesthetic effect of bupivacaine liposomes in rats. International Journal of Pharmaceutics (Amsterdam) 176(1): 133-136, 1998

LH response to LH-RH neonatally estrogenized male rats. Andrologia 17(3): 254-256, 1985

Central projections of primary sensory afferents to the spinal dorsal horn in the long-tailed stingray, Himantura fai. Brain Behavior and Evolution 76(1): 60-70, 2010

Naked-eye Detection of Hg 2+ in Practical Applications Using a Highly Selective and Sensitive Fluorescent Probe. Analytical Sciences 34(12): 1411-1417, 2018

Dispersal and mortality of juvenile American Black Ducks, Anas rubripes, on wetlands under different management strategies. Canadian Field-Naturalist 112(4): 586-595, 1998