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Transforming growth factor-betas: smad signaling and roles in physiopathology


Transforming growth factor-betas: smad signaling and roles in physiopathology



Pathologie-Biologie 52(1): 50-54



ISSN/ISBN: 0369-8114

PMID: 14761714

DOI: 10.1016/j.patbio.2003.10.002

Transforming growth factor-beta (TGF-beta) family members are multifunctional peptide growth factors that regulate cell growth, differentiation, extracellular matrix production and cell migration and embryonic development. Knock-out experiments for the three mammalian isoforms of TGF-beta in mice have demonstrated their importance in regulating inflammation and tissue repair. Also, TGF-beta has been implicated in the pathogenesis of human diseases, including tissue fibrosis and carcinogenesis. In the latter case, it may exert both tumor suppressor and pro-oncogenic activities depending on the stage of the tumor. Smads proteins constitute the core components of the intracellular signaling cascade initiated by TGF-beta receptors, as they carry signals from the cell surface directly to the nucleus; where they act as transcription factors.

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Accession: 035973606

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Related references

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