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Treatment and prevention of disorders mediated by LA-paf or endothelial cells

Treatment and prevention of disorders mediated by LA-paf or endothelial cells

Official Gazette of the United States Patent & Trademark Office Patents 1221(3), 19-JUL-99

The invention refers to the composition of substances to prevent and treat endothelial cell-mediated disorders with pathological differentiation of endothelial cells, for example, in response to insulin, lipids, lipoproteins or LA-paf. The invention refers to simple methods to test and use antagonists against LA-paf, paf and very high affinity receptors on endothelial cells which can also be cultured on soluble particles for screening procedures. According to the invention genes producing very high affinity receptors, for example, in response to growth factors such as insulin. These genes can be transferred from adherent endothelial cell lines to soluble cells using standard procedures. Antagonists against LA-paf, paf and very high affinity receptors are administered by preference to healthy persons having risk factors to protect against aging and metabolic, genetic, chronicle, idiopathic, inflammatory or degenerative disorders. The antagonists can be administered by preference with food or topically, for example, with beauty products.

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Accession: 035980017

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