EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Treatment of Alzheimer's disease by transposition of the omentum



Treatment of Alzheimer's disease by transposition of the omentum



Annals of the New York Academy of Sciences 977: 454-467



There is increasing evidence that cerebral hypoperfusion plays a key role in the development of Alzheimer's disease (AD). As one ages, cerebral blood flow (CBF) decreases as a direct reflection of a normal aging process. Coupled with this expected drop in CBF are a host of other factors, such as hypertension, stress, smoking, diabetes, cholesterol buildup, etc., which further decrease blood flow to the brain. Maintaining a critical level of CBF is essential if adequate amounts of oxygen and glucose are to be presented to neurons to sustain their cellular energy production (ATP). If CBF drops below a critical flow level, insufficient ATP will be produced and, if this situation is not corrected, neurons will deteriorate and eventually die. When a critical mass of neurons die in areas of the brain involved with cognition and memory, AD will result. Omentum transposition to the brain is a surgical procedure by which a large volume of blood and other biological agents can be delivered to the brain over an indefinite period of time. The omentum gives metabolic support to deteriorating neurons and its presence on the brain has resulted in the reversal of AD symptoms. Additionally, omentum transposition to the brain can markedly reduce senile plaque accumulation, but has no apparent effect on reducing neurofibrillary tangles. Omental transposition may play an important role in the future treatment of AD, especially in early and moderate cases.

(PDF emailed within 0-6 h: $19.90)

Accession: 035980328

Download citation: RISBibTeXText

PMID: 12480786

DOI: 10.1111/j.1749-6632.2002.tb04851.x



Related references

Omentum transposition surgery for patients with Alzheimer's disease: a case series. Neurological Research 30(3): 313-325, 2007

The evolution of omentum transposition: from lymphedema to spinal cord, stroke and Alzheimer's disease. Neurological Research 26(5): 586-593, 2004

Role of the omentum in the treatment of Alzheimer's disease. Neurological Research 23(6): 555-564, 2001

Omental transposition in treatment of Alzheimer disease. Journal of the American College of Surgeons 205(6): 800-804, 2007

Transposition of the greater omentum in the prevention and treatment of radiation injury. Netherlands Journal of Surgery 43(5): 161-166, 1991

Extra-abdominal transposition of the greater omentum in the treatment of lymphedema. Harefuah 96(2): 79-81, 1979

Preliminary experience employing transposition of the omentum in the treatment of infected vascular lesions. Langenbecks Archiv fuer Chirurgie 359(2): 123-132, 1983

Transposition of greater omentum for treatment of spinal cord injury experimental and clinical study. Zhonghua Guke Zazhi 9(4): 269-271, 318-319, 1989

Treatment of mediastinal infection after coronary artery bypass surgery by transposition of the greater omentum. Nihon Kyobu Geka Gakkai 39(12): 2152-2156, 1991

Infected ascending aortic prosthesis: successful treatment by thoracic transposition of the greater omentum. European Journal of Cardio-Thoracic Surgery 9(4): 223-225, 1995

Thoraco-brachial transposition of the greater omentum as a new surgical method in the treatment of postoperative lymphedema. Minerva Chirurgica 26(17): 947-952, 1971

Thoracic transposition of the greater omentum as an adjunct in the treatment of mediastinitis--pros and cons within the context of a randomised study. European Journal of Surgery. Supplement. 584): 45-48, 2000

Omental transposition for Alzheimer 's disease. Neurological Research 18(2): 103-108, 1996

Application of 3D printing technology in the treatment of humeral intercondylar fractures. Orthopaedics & Traumatology, Surgery & Research, 2017

Transposition of the omentum. Der Chirurg; Zeitschrift für Alle Gebiete der Operativen Medizen 48(6): 369-376, 1977