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Treatment of Sjogrens syndrome

Treatment of Sjogrens syndrome

Reumatologia 41(4): 419-424

Treatment of Sjogren's syndrome depends on both topical and systemic therapy. Topical treatment of dry eye depends on the use of ocular lubricans. Treatment of dry mouth includes intensive dental hygiene and use of artificial saliva. Systemic therapy are useful for manifestations such as arthritis, pneumonitis, nephritis and neurologic symptoms; however their ability to improve salivary or tear flow has been relatively disappointing. Pilocarpine and cevimeline are recomended for treatment dry eye and mouth and that treatment is safe and effective. Corticosteroids, antimalarials is not effective and then is no improvement in objective symptoms of dry eye and mouth after methotrexate treatment. Increased lacrimal and saliva secretion was observed after alpha interferon and zidovudine treatment.

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Accession: 035980616

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DOI: 10.1111/j.1444-0938.1976.tb02202.x

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