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Treatment of accidental extravasation of anthracyclines



Treatment of accidental extravasation of anthracyclines



Official Gazette of the United States Patent & Trademark Office Patents 1281(4), Apr 27



The present invention relates to a method for pharmacological treatment of accidental extravasation of topoisomerase II poisons, such as anthracyclines. In particular, the invention relates to the use of a topo II catalytic inhibitor, such as the bisdioxopiperazine ICRF-187, for the treatment of an accidental extravasation of a topoisomerase II poison. A method for treatment of such extravasation of a topoisomerase poison such as the anthracyclines, daunorubicin, doxorubicin, epirubicin, or idarubicin is disclosed.

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Accession: 035980699

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