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Treatment of an adult with acute myeloid leukemia by two unit HLA-mismatched unrelated umbilical cord blood transplantation



Treatment of an adult with acute myeloid leukemia by two unit HLA-mismatched unrelated umbilical cord blood transplantation



Blood 102(11): 472b, November 16



Objective: To explore the hematopoietic and immunologic reconstitution and engraftment status after transplantation of umbilical-cord blood from two units HLA one locus mismatched unrelated donores. Methods: A 41-year old, 75-Kg man with acute myeloid leukemia in complete remission received two units HLA-mismatched unrelated umbilical cord blood transplantation. The conditioning regimens were BU/CY/ATG. GVHD prophylaxis regimens consisted of cyclosporine(CSA) and mycophenolate mofetil(MMF). The infused doses of nucleated cells were 2.47X107/Kg (donor1) and 1.4X107/Kg (donor2). Results: An absolute neutrophil count more than 0.5X109/l occurred at day 19, NK cell and B cell counts were normalized by day +30 and +120. No acute or chronic graft versus host disease(GVHD) occurred in the follow-up duration of 180 days. DNA-STR and HLA distinct alleles assay revealed a complete chimerism of two Donors. Conclusion: HLA 1 loic-mismatched UBCT can produce a hematopoietic and immunologic reconstitution 2 units of UCBT are feasible for adult patients.

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Accession: 035980925

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