EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Tremor-related neurons in the globus pallidus internus and subthalamic nucleus in parkinsonian patients



Tremor-related neurons in the globus pallidus internus and subthalamic nucleus in parkinsonian patients



Society for Neuroscience Abstracts 27(1): 1353



Parkinsonian tremor is supposed generated by a central oscillator that entrains the basal ganglia motor circuits. In the circuits, tremor cells are presumed to play a role in the pathogenesis of tremor. To test these hypotheses, we studied cells in tracks that passed through the globus pallidus internus (GPi) and subthalamic nucleus (STN) respectively during microelectrode-guided stereotactic neurosurgery. The electromyograms (EMG) were recorded simultaneously from the contralateral limbs during surgery. Single unit analysis was carried out. Cross correlation was performed to study cell firing in relation to limb tremor. In the present study, the 184 GPi cells in 21 Parkinson's disease (PD) patients and 134 STN cells in 25 PD patients were recorded. In GPi, 86 tremor cells (47%) of 184 GPi cells had spike firing at the same average frequency (4.2-5.4 Hz) as parkinsonian tremor measured from EMG, and the cross correlation of frequency of tremor cells with limb tremor were highly correlated (R2=0.78, P<0.01). Those GPii tremor cells with the mean firing rate at 124+-21Hz were mostly located 4-6 mm above the optic tract. In STN, 51 tremor cells (38%) of 134 STN cells had spike firing at the same average frequency (3.6-5.2 Hz) as tremor measured from EMG. Similarly, the cross correlation test showed that tremor cells in STN are highly correlated with limb tremor (R2=0.69, P<0.01). Lesioning of those tremor cells abolished tremor symptom in all patients. The existance of tremor cells suggesting that both GPi and STN are involved in tremorgenesis. The results support for the prediction of the pathophysiologic models of the basal ganglia in PD.

(PDF 0-2 workdays service: $29.90)

Accession: 035985048

Download citation: RISBibTeXText



Related references

Effects of apomorphine on subthalamic nucleus and globus pallidus internus neurons in patients with Parkinson's disease. Journal of Neurophysiology 86(1): 249-260, 2001

Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease. Journal of Neurosurgery 101(2): 195-200, 2004

Involvement of the subthalamic nucleus and globus pallidus internus in attention. Journal of Neural Transmission 118(8): 1235-1245, 2012

Effects of subthalamic nucleus and globus pallidus internus stimulation on procedural learning. Neurology 48(3 SUPPL 2): A118, 1997

Bilateral implantation in globus pallidus internus and in subthalamic nucleus in Parkinson's disease. Neuromodulation 8(1): 1-6, 2005

Which target for DBS in Parkinson's disease? Subthalamic nucleus versus globus pallidus internus. Neurological Sciences 22(1): 87-88, February, 2001

Comparison between subthalamic nucleus and globus pallidus internus stimulation for postural performance in Parkinson's disease. Gait & Posture 19(2): 172-183, 2004

Subthalamic nucleus and globus pallidus internus stimulation for the treatment of Parkinson's disease: A systematic review. Journal of International Medical Research 45(5): 1602-1612, 2017

The human subthalamic nucleus and globus pallidus internus differentially encode reward during action control. Human Brain Mapping 38(4): 1952-1964, 2017

Placement of deep brain stimulators into the subthalamic nucleus or Globus pallidus internus: technical approach. Stereotactic and Functional Neurosurgery 79(3-4): 118-145, 2003

Single-unit activity of the anterior Globus pallidus internus in Tourette patients and posterior Globus pallidus internus in dystonic patients. Clinical Neurophysiology 128(12): 2510-2518, 2017

Deep brain stimulation for the treatment of Parkinson's disease: subthalamic nucleus versus globus pallidus internus. Journal of Neurology, Neurosurgery, and Psychiatry 70(4): 464-470, 2001

Weight change after globus pallidus internus or subthalamic nucleus deep brain stimulation in Parkinson's disease and dystonia. Stereotactic and Functional Neurosurgery 90(6): 386-393, 2013

Weight Change after Globus Pallidus Internus or Subthalamic Nucleus Deep Brain Stimulation in Parkinsons Disease and Dystonia. Stereotactic and Functional Neurosurgery 90(6): 386-393, 2012

A comparison of discharge pattern of internal segment neurons of the globus pallidus in akinetic and tremor Parkinsonian patients. Society for Neuroscience Abstracts 23(1-2): 470, 1997