EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Trends in legionnaires disease, 1980-1998: declining mortality and new patterns of diagnosis



Trends in legionnaires disease, 1980-1998: declining mortality and new patterns of diagnosis



Clinical Infectious Diseases 35(9): 1039-1046



New diagnostic tests and empirical therapy for pneumonia may have important ramifications for the identification, treatment, and control of legionnaires disease (LD). To determine trends in the epidemiology of LD, we analyzed data for 1980-1998 from the passive surveillance system of the Centers for Disease Control and Prevention. During this time period, there were 6757 confirmed cases of LD (median annual number, 360 cases/year). Diagnosis by culture and by direct fluorescent antibody and serologic testing decreased significantly; diagnosis by urine antigen testing increased from 0% to 69%. The frequency of isolates other than Legionella pneumophila serogroup 1 (LP1) decreased from 38% to 4% (P = .003). The case-fatality rate decreased significantly, from 34% to 12% (P < .001) for all cases, from 46% to 14% (P < .0001) for nosocomial cases, and from 26% to 10% (P = .05) for community-acquired cases.LD-related mortality has decreased dramatically. The decrease in culture-based diagnosis limits the recognition of non-LP1 disease and impairs outbreak investigation, because fewer Legionella isolates are provided for further examination.

(PDF same-day service: $19.90)

Accession: 035985154

Download citation: RISBibTeXText

PMID: 12384836

DOI: 10.1086/342903



Related references

Declining mortality from stroke in Allegheny County, Pennsylvania. Trends in case fatality and severity of disease, 1971-1980. Stroke 19(2): 181-184, 1988

Declining mortality from stroke in allegheny county pennsylvania usa trends in case fatality and severity of disease 1971 1980. Stroke 19(2): 181-184, 1988

Trends and Patterns of Differences in Infectious Disease Mortality Among US Counties, 1980-2014. JAMA 319(12): 1248-1260, 2018

Trends and Patterns of Differences in Chronic Respiratory Disease Mortality Among US Counties, 1980-2014. JAMA 318(12): 1136-1149, 2017

Breast cancer mortality patterns and time trends in 10 new EU member states: mortality declining in young women, but still increasing in the elderly. International Journal of Cancer 112(6): 1056-1064, 2004

Surveillance for Legionnaires disease 1980-1989 Risk factors for disease and disease-related mortality. Program & Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 33(0): 373, 1993

Trends in mortality due to respiratory diseases in elderly, Brazil, 1980 to 1998. Revista de Saude Publica 37(2): 191-196, 2003

Trends in hypertension-related mortality in the United States, 1980-1998. Journal of the American College of Cardiology 41(6 Supplement A): 277A, March 19, 2003

Trends in coronary heart disease and stroke mortality The Brazilian heart and stroke surveys, 1980 through 1998. Circulation 106(19 Supplement): II 725, November 5, 2002

Mortality trends in systemic sclerosis in France and USA, 1980-1998: an age-period-cohort analysis. European Journal of Epidemiology 25(1): 55-61, 2010

Trends and spatial distribution of oral cancer mortality in São Paulo, Brazil, 1980-1998. Oral Oncology 37(4): 345-350, 2001

Time trends in long-term mortality after out-of-hospital cardiac arrest, 1980 to 1998, and predictors for death. American Heart Journal 145(5): 826-833, 2003

Trends in mortality and years of life lost related to alcohol in the Canary Islands, Spain [1980-1998]. Gaceta Sanitaria 17(6): 466-473, 2003

Declining mortality from ischemic heart disease and changes in coronary risk factors in Japan, 1956-1980. American Journal of Epidemiology 125(1): 62-72, 1987

Disparities in mortality patterns among Canadian immigrants and refugees, 1980-1998: results of a national cohort study. Journal of Immigrant Health 7(4): 221-232, 2009