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Trends in antimicrobial resistance in Canadian strains of Streptococcus pneumoniae, 1988-2003



Trends in antimicrobial resistance in Canadian strains of Streptococcus pneumoniae, 1988-2003



Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 43: 128



Background: The Canadian Bacterial Surveillance Network is a collaborative network of microbiology laboratories that submit bacterial isolates to a central laboratory for standardized antimicrobial susceptibility testing. This group has been monitoring resistance trends in Canadian isolates of Streptococcus pneumoniae (SP) since 1988. Methods: 18,525 SP isolates from 192 labs have been submitted for susceptibility testing according to NCCLS protocols. Data on outpatient antibiotic use was obtained from IMS Canada. 422 isolates collected in 2003 were tested against daptomycin and linezolid. Results: Of the 18,525 SP isolates, 37.8% were from blood/CSF, 28.2% from sputum, 17.9% from eyes, 7.4% from ears. The overall use of macrolides is stable while fluoroquinolone use continues to rise in Canada. Trends in antimicrobial susceptibility are expressed below as percentage resistant. All isolates had MICs ltoreq0.25 for daptomycin and ltoreq2 for linezolid. Conclusions: Despite decreasing outpatient use of penicillin, TMP/SMX, and tetracycline, there has been little impact on the resistance rates to these agents. Preliminary data from isolates tested in 2003 suggests a significant decrease in resistance to erythromycin, perhaps in response to stabilization in overall use of macrolides. Despite the continued increase in fluoroquinolone use, resistance to ciprofloxacin appears to have stabilized and may in fact be decreasing.

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