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Trends in clinically significant lipid disorders at San Francisco General Hospital using HIVWatch A web based electronic clinical database

Trends in clinically significant lipid disorders at San Francisco General Hospital using HIVWatch A web based electronic clinical database

Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 41: 315

Introduction: Treatment for HIV-1 has focused on RCT, however observational databases can provide key real world experiences. One key issue with ART is the rapid appearance of disorders of fatty tissue or lipids, often grouped as lipodystrophy. Using an electronic database, HIVWatch, we evaluated the incidence of fatty abnormalities based on ICD-9 codes. Methods: HIVWatch was used to record medications and ICD-9 codes. ICD-9 codes consistent with lipodystrophy were evaluated. Results: A total of 126 patients received an ICD-9 diagnosis consistent with abnormal fat or lipodystrophy (coded 272.X) and had or receiving ART. The mean CD4 and VL for persons with or without a 272 dx were 411 and 318 cells and 225 and 735 c/mL respectively (p<0.01). The likelihood of receiving a specific ART medication among patients with an 272 ICD-9 code are given. Conclusions: Using HIVWatch, we noticed a trend that linked the 126 patients with an ICD-9 diagnostic code for lipid abnormalities to ART. The most common medications were protease inhibitors and ritonavir was the most often linked to lipodystrophy. D4T and 3TC were less commonly linked to an ICD-9 diagnosis of lipodystrophy than was abacavir.

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Accession: 035985276

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