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Trends in community prescribing in Scotland, 1992-99, and associations with resistant pneumococci



Trends in community prescribing in Scotland, 1992-99, and associations with resistant pneumococci



Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 41: 489



Background: Interest is increasing in controlling antibiotic prescribing for both financial and ecological reasons. Methods: Community antibiotic prescribing in Scotland has been documented for the last 8 years through a national pharmacy reimbursement scheme. Results: Total prescribing in 1999 was 617 DDD per 100 population per year (WHO AR classification) which represented a decline of 1.8% since 1992. This represented a reversal of a peak around 1995. Comparing 1999 data with 1995 the reduction was 13%. Six British National Formulary sub-sections accounted for more than 95% of DDDs prescribed are given. In 1999 amoxycillin was used twice as often as the second most common agent oxytetracycline, followed by erythromycin, trimethoprim, minocycline, co-amoxiclav, doxycline and penicillin V. Detailed data on macrolide was analyzed, related to resistance in pneumococci and compared with data from other countries. In 1999 erythromycin preparations accounted for over 80 DDD per 100 population/year while clarithromycin DDD's over 21 and azithromycin <1. Resistance to macrolides and penicillin in pneumococci remains low (<5%) compared to other countries in Europe. Conclusions: Community antibiotic use in Scotland is relatively conservative, is decreasing and is associated with low resistant rate in pneumococci.

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Accession: 035985279

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