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Trends in helicobacter pylori eradication rate in korea since 1998 to 2002 ppi based triple therapy



Trends in helicobacter pylori eradication rate in korea since 1998 to 2002 ppi based triple therapy



Digestive Disease Week Abstracts & Itinerary Planner : Abstract No M1832



Introduction: Antimicrobial resistance is largely responsible for H. pylori eradication treatment failure. Recent increase in clarithromycin-resistant strains may result in H. pylori eradication failure. But there is no reports about that in Korea. The aim of this study is to assess the trend in Helicobacter pylori eradication rate of PPI based triple therapy in Korea since 1998 to 2002. Methods: H. pylori-positive 1150 patients confirmed by 13C-UBT, who had received OAC triple therapy for 7 days or 14 days during June 1998 and May 2002 were included in this study. Four weeks after completion of the eradication therapy, success of eradication was determined by 13C-UBT. The eradication rate per year was compared. Results: Successful eradication rate following OAC triple therapy for 7 days did not show significant changes (p=0.298), but eradication rate following OAC triple therapy for 14 days show a significant decreasing tendency (p=0.001). Conclusion: Helicobacter pylori eradication rate of PPI based triple therapy showed downward tendency in recent years, especially 14 days regimen. This result suggests that new alternative H. pylori eradication treatment regimen may be necessary to cope with the increase in the antibiotic-resistant strains.

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Accession: 035985356

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