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Trends in prescribing of anti-hypertensive drugs in a tertiary care hospital in Delhi

Trends in prescribing of anti-hypertensive drugs in a tertiary care hospital in Delhi

Indian Journal of Pharmacology 33(3): 236-237

Introduction: Drug utilization studies can be used to monitor appropriateness, safety and cost-effectiveness of prescribing. Objective: To study the trends in prescribing of anti-hypertensive agents. Methods: A descriptive prospective study was conducted in cardiology and medicine OPD of LHMC and associated hospital between December 99-August 2000. Prescriptions of all patients who had hypertension with or without other concomitant illness were noted. Results: Out of 83 patients of hypertension (HT), 22 (26.5%) patients had coronary artery disease (CAD), 10 (12%) had diabetes mellitus (DM), 5 (6%) had other complications of hypertension and 6 (7%) had associated bronchial asthma. Amlodipine (20/40 (50%)), atenolol (18/40 (45%)), enalapril (17/40 (42.5%)) were frequently used anti-hypertensives in patients with a diagnosis of essential HT. Patients of HT with CAD received amlodipine (13/22 (59%)) and atenolol (11/22 (50%)) while patients of HT with DM received enalapril (8/10 (80%)) and furosemide (4/10 (40%)) more frequently. Blood-pressure remained uncontrolled in at least 4/10 patients of hypertension with diabetes mellitus. Adverse effects to drugs were seen in 14 (17%) cases. Commonly encountered adverse effects were restlessness (4), headache (3) and weakness (3). Presence of concomitant illness increased the cost of prescription. Conclusions: Drugs per prescription were 4.93. Amlodipine was most commonly used drug in essential HT and HT with CAD while enalapril was most frequently used in HT with DM.

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