+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Trends in resistance among Enterobacteriaceae isolated from inpatients and intensive-care unit patients in the US from 1998 to 2001

Trends in resistance among Enterobacteriaceae isolated from inpatients and intensive-care unit patients in the US from 1998 to 2001

Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 42: 92

Background: Members of the family Enterobacteriaceae (EB) are among the most important human pathogens and account for approximately 50% of all clinically significant isolates of bacteria identified in hospital laboratories. Ongoing monitoring for antimicrobial resistance in species of EB is important, as resistance has been reported to be associated with increased patient morbidity and mortality, prolonged hospitalization, and increased hospital expenditures. Methods: Inpatient (IP) and intensive-care unit patient (ICUP) isolate data from The Surveillance Network Database-USA were used to assess the in vitro activities of ampicillin-sulbactam (AS), ceftriaxone (CT), ceftazidime (CZ), piperacillin-tazobactam (PT), imipenem (IM), gentamicin (GT), trimethoprim-sulfamethoxazole (TS), ciprofloxacin (CP), and levofloxacin (LV) against EB (n=440,152). Results: From 1998 to 2001, all isolates of E. coli (EC), K. pneumoniae (KP), S. marcescens (SM), E. cloacae (EE), E. aerogenes (EA), and C. freundii (CF) were susceptible to IM. Among EC isolates from IPs and ICUPs, resistance (R) to AS was consistently gtoreq20% and fluoroquinolone (FQ) R more than doubled among both IP (1998, 3.1-4.2%; 2001, 8.4-8.7%) and ICUP isolates (1998, 3.3-5.5%; 2001, 10.8-11.4%). In 2001, among all species of EB studied except SM, FQ R was more commonly found as a component of multidrug-resistant (MDR; R to gtoreq3 agents) isolates than as a single drug-resistance phenotype. For EC and KP, ICUP isolates were resistant more often than were IP isolates to a FQ, GT, CT, PT, and TS. Conclusions: FQ resistance among EB showed the greatest relative increases in R from 1998 to 2001 suggesting perhaps that the cumulative use of these agents may be driving resistance. Resistance to CT, PT, GT, and TS was also common (>5%) among several species of EB. All MDR isolates from IPs and ICUPs were susceptible to IM.

(PDF 0-2 workdays service: $29.90)

Accession: 035985514

Download citation: RISBibTeXText

Related references

Trends in antimicrobial susceptibilities among Enterobacteriaceae isolated from hospitalized patients in the United States from 1998 to 2001. Antimicrobial Agents and ChemoTherapy 47(5): 1672-1680, 2003

Surveillance of antimicrobial resistance among uncommon Enterobacteriaceae isolated from intensive care units during 1994-2001 in China. Zhonghua Weishengwuxue He Mianyixue Zazhi 24(1): 31-35, January, 2004

Study on drug resistance of Staphylococcus aureus isolates from the inpatients in the internal medicine, surgery, intensive care unit, and the outpatients from 1996-2001. Zhongguo Kangshengsu Zazhi 28(4): 207-211, 2003

Bacterial resistance to antibiotics in gram-negative rods isolated from intensive care units. Comparative analysis between two periods (1998 and 2001). Medicina 63(1): 21-27, 2003

Chemoantibiotic resistance of microorganisms isolated from intensive care unit patients. Igiene Moderna 92(6): 1337-1344, 1989

Trends in resistance among gram-negative bacilli from intensive care unit patients in Italy from 1999 to 2002. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 43: 148, 2003

In vivo evolution of resistance of Pseudomonas aeruginosa strains isolated from patients admitted to an intensive care unit: mechanisms of resistance and antimicrobial exposure. Journal of Antimicrobial ChemoTherapy 70(11): 3004-3013, 2016

Synergistic impact of low serum albumin on intensive care unit admission and high blood urea nitrogen during intensive care unit stay on post-intensive care unit mortality in critically ill elderly patients requiring mechanical ventilation. Geriatrics & Gerontology International 13(1): 107-115, 2013

Development of resistance to aminoglycosides among coagulase-negative staphylococci and enterobacteriaceae in a neonatal intensive care unit. Journal Of Hospital Infection. 24(1): 39-46, 1993

Antimicrobial resistance of Gram-negative bacilli isolated from patients in intensive care unit. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 17(7): 409-411, 2005

Antibiotic resistance profiles of Acinetobacter sp. strains isolated from intensive-care unit patients. Roumanian Archives of Microbiology and Immunology 71(2): 75-80, 2012

Resistance of six frequently isolated bacteria in intensive care unit patients to some cephalosporins and aminoglycosides. Journal of ChemoTherapy 1(4 Suppl): 323-323, 1989

Ciprofloxacin-resistant enterobacteria harboring the aac(6')-Ib-cr variant isolated from feces of inpatients in an intensive care unit in Uruguay. Antimicrobial Agents and ChemoTherapy 52(2): 806-807, 2007

Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001). International Journal of Antimicrobial Agents 24(2): 111-118, 2004

Emergence of colistin resistance in Enterobacteriaceae after the introduction of selective digestive tract decontamination in an intensive care unit. Antimicrobial Agents and ChemoTherapy 57(7): 3224-3229, 2014