+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Trends in the epidemiology and outcome of barretts esophagus in southern europe

Trends in the epidemiology and outcome of barretts esophagus in southern europe

Digestive Disease Week Abstracts and Itinerary Planner: Abstract No. W1289

INTRODUCTION: The proportion of Barrett's Esophagus (BE) that progresses to esophageal adenocarcinoma is critical for developing follow up strategies. There are no data of trends and outcomes of BE in Europe.AIMS: To identify changes in the incidence, prevalence and outcome of BE in a defined population in Spain.SUBJECTS & METHODS: Residents of Area III of Zaragoza, Spain, (250,000 inhabitants) with clinically diagnosed BE. The entire population of the area has open access to all health resources of the community and a single Endoscopy Unit has been operative for the last 28 years in this area. The records of this Unit were reviewed from January 1st,1976 to December 31st,2001. Follow up was performed until January 1st,2002.RESULTS: 491 cases of clinically diagnosed BE were identified over 26 years. The crude incidence increased 19-fold from 1.5/100,000 person years in the period 1976-1978 to 28.5/100,000 in 1999-2001 (15.7-fold for age and sex adjusted rates). In the same period of time upper GI endoscopic examinations increased 1.9-fold. However, the number of upper endoscopy examinations has not increased for the last 6 years, but the incidence of diagnosed BE has shown a 4-fold increase from 8/100,000 person years in 1997 to 32/100,000 in 2001. The crude prevalence of diagnosed BE increased from 12/100,000 person years in 1985 to 163/100,000 in 2001. The prevalence of short segment BE (<3cm) in 2001 was 99/100,000.A total of 40 cases of dysplasia and 24 of esophageal cancer were diagnosed. During follow up, which could be traced in 72% of patients without either dysplasia or carcinoma at diagnosis, 11 patients developed dysplasia and 10 carcinoma (6 adenocarcinomas, 2 schamous carcinomas, 1 undifferentiated and 1 unknown) for a rate of 1 case in 93 patient years for dysplasia and 1 case in 109 patient years for carcinoma.CONCLUSIONS: The Incidence and prevalence of clinically diagnosed Barrett's Esophagus have dramatically increased in our comunity, which is only partially explained by the increased use of endoscopy. Both adenocarcinoma and schamous carcinoma develops in patients with BE, but this compliacation is less frequent than previously reported.

Accession: 035985584

Download citation: RISBibTeXText

DOI: 10.1016/s0016-5085(03)83248-1

Related references

Trends in Barrett's esophagus diagnosis in Southern Europe: implications for surveillance. Diseases of the Esophagus 22(3): 239-248, 2009

Recurrence of columnar lined esophagus segments after surgery for Barretts associated adenocarcinoma The natural history of Barretts esophagus. Gastroenterology 118(4 Suppl 2 Part 1): A222, 2000

Quantitative mRNA expression analysis of multiple genes distinguish between Barretts-esophagus and Barretts-associated adenocarcinoma of the esophagus. Proceedings of the American Association for Cancer Research Annual Meeting 43: 464-465, 2002

Study of p53 gene mutations and serum anti-p53 antibodies in Barretts esophagus and short segment Barretts esophagus. Gastroenterology 118(4 Suppl 2 Part 2): AGA A1319, 2000

The role of retinoid x receptor mrna expression in barretts esophagus and barretts associated adenocarcinoma of the esophagus. Digestive Disease Week Abstracts and Itinerary Planner: Abstract No. 501, 2003

Epidemiology and Significance of Barretts Esophagus. Digestive Diseases 18(4): 195-202, 2000

Pathogenesis and epidemiology of Barretts esophagus. Chirurg 65(2): 84-87, 1994

Epidemiology of Barretts esophagus and esophageal adenocarcinoma. Diseases of the Esophagus 8(2): 86-92, 1995

Trends in the diagnosis and monitoring of barretts esophagus. Digestive Disease Week Abstracts and Itinerary Planner: Abstract No. M1757, 2003

Racial differences in the prevalence of long segment Barretts esophagus, short segment Barretts esophagus and specialized columnar epithelium at the gastroesophageal junction. Gastroenterology 110(4 Suppl. ): A79, 1996

Curative endoscopic therapy of early cancer and high grade neoplasia in barretts esophagus additional endoscopic ablation of barretts esophagus can reduce the risk of recurrent carcinomas. Digestive Disease Week Abstracts and Itinerary Planner: Abstract No. W1270, 2003

Barretts esophagus Epidemiology and natural history of tumoral progression. Gastroenterologie Clinique et Biologique 23(5 Suppl. ): B12-B19, 1999

Short segment Barretts esophagus Prevalence of Helicobacter pylori infection in comparison to patients with erosive GERD, long segment Barretts esophagus as well as a asymptomatic control group A prospective evaluation. Gastroenterology 118(4 Suppl 2 Part 2): AGA A1303, 2000

Analysis of Barretts esophagus causes and risk factors for dysplasia and drug treatment to reverse dysplasia in Barretts esophagus. American Journal of Gastroenterology 98(9 Suppl.): S27, 2003

Molecular epidemiology of Barretts esophagus and cancer A population-based case-control Study. Cancer Epidemiology Biomarkers and Prevention 12(11 Part 2): 1349s-1350s, 2003