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Tri- and tetra-valent monospecific antigen-binding proteins



Tri- and tetra-valent monospecific antigen-binding proteins



Official Gazette of the United States Patent & Trademark Office Patents 1266(4), Jan 28



The invention provides a tri- or tetra-valent monospecific antigen-binding protein comprising three or four Fab fragments bound to each other covalently by a connecting structure, which protein is not a natural immunoglobuline. Further provided are novel connecting structures for use in assembling the proteins of the invention and means for attaching a labeling or effector group thereto. The proteins of the invention are useful, for example, in the treatment and diagnosis of cancer.

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Accession: 035985770

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