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Tri-n-butyltin at environmentally-relevant concentration modulates pre- and postsynaptic responses in the rat CNS



Tri-n-butyltin at environmentally-relevant concentration modulates pre- and postsynaptic responses in the rat CNS



Society for Neuroscience Abstracts 27(1): 892



Tri-n-butyltin (TBT), an antifouling agent, is highly accumulated in mollusks and fishes, and its affection to predators including human becomes one of health concerns. To see possible neurotoxic actions of TBT, we have examined TBT effect on spontaneous GABAergic synaptic transmission and N-metyl-D-asparatate (NMDA)-induced current in rat ventromedial hypothalamus (VMH) neurons using a nystatin perforated patch recording mode, because TBT increases neuronal Ca2+ concentration. TBT at 30 nM or higher increased frequency of GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in a dose-dependent manner in VMH neurons. The mean amplitude and current kinetics of mIPSCs were not significantly affected by nanomolar concentrations of TBT. On the other hand, TBT at 100nM did not affect the NMDA-induced inward current, but greatly enhanced the NMDA-induced Ca2+ activated outward current. Present results indicate that TBT at environmentally relevant concentrations (30-100nM) facilitates GABA release from the presynaptic nerve terminal and potentates postsynaptic NMDA-induced outward current by increasing Ca2+ influxes. Although it may be difficult to exactly estimate the neurotoxicity of TBT from the present in vitro studies, it is greatly suspected that TBT accumulated in some mollusks and fishes might become hazardous to human health.

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Accession: 035985792

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