+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Tri-n-butyltin at environmentally-relevant concentration modulates pre- and postsynaptic responses in the rat CNS

Tri-n-butyltin at environmentally-relevant concentration modulates pre- and postsynaptic responses in the rat CNS

Society for Neuroscience Abstracts 27(1): 892

Tri-n-butyltin (TBT), an antifouling agent, is highly accumulated in mollusks and fishes, and its affection to predators including human becomes one of health concerns. To see possible neurotoxic actions of TBT, we have examined TBT effect on spontaneous GABAergic synaptic transmission and N-metyl-D-asparatate (NMDA)-induced current in rat ventromedial hypothalamus (VMH) neurons using a nystatin perforated patch recording mode, because TBT increases neuronal Ca2+ concentration. TBT at 30 nM or higher increased frequency of GABAergic miniature inhibitory postsynaptic currents (mIPSCs) in a dose-dependent manner in VMH neurons. The mean amplitude and current kinetics of mIPSCs were not significantly affected by nanomolar concentrations of TBT. On the other hand, TBT at 100nM did not affect the NMDA-induced inward current, but greatly enhanced the NMDA-induced Ca2+ activated outward current. Present results indicate that TBT at environmentally relevant concentrations (30-100nM) facilitates GABA release from the presynaptic nerve terminal and potentates postsynaptic NMDA-induced outward current by increasing Ca2+ influxes. Although it may be difficult to exactly estimate the neurotoxicity of TBT from the present in vitro studies, it is greatly suspected that TBT accumulated in some mollusks and fishes might become hazardous to human health.

(PDF emailed within 1 workday: $29.90)

Accession: 035985792

Download citation: RISBibTeXText

Related references

Tri-n-butyltin at environmentally-relevant concentrations facilitates synaptic transmission in rat brain neurons. Japanese Journal of Pharmacology 85(Supplement 1): 132P, 2001

Methodologic approaches for detecting effects of environmentally relevant chemicals on fishes: exemplified by bis-(tri-n-butyltin)-oxide (TBTO). Schriftenreihe des Vereins für Wasser-, Boden- und Lufthygiene 89: 147-155, 1992

Toxic effect of environmentally relevant concentration of silver nanoparticles on environmentally beneficial bacterium Pseudomonas putida. Bioprocess and Biosystems Engineering 38(7): 1243-1249, 2016

Effects of an environmentally relevant concentration of diuron on oyster genitors during gametogenesis: responses of early molecular and cellular markers and physiological impacts. Environmental Science and Pollution Research International 23(8): 8008-8020, 2016

Histopathological effects of chronic aqueous exposure to bis(tri-n-butyltin)oxide (TBTO) to environmentally relevant concentrations reveal thymus atrophy in European flounder (Platichthys flesus). Environmental Pollution 157(10): 2587-2593, 2011

Proteomic 2D DIGE profiling of human vascular endothelial cells exposed to environmentally relevant concentration of endocrine disruptor PCB153 and physiological concentration of 17β-estradiol. Cell Biology and Toxicology 27(1): 49-68, 2011

TLR4 is a target of environmentally relevant concentration of lead. Toxicology Letters 214(3): 301-306, 2013

Passive sampling for volatile organic compounds (VOCs) in air at environmentally relevant concentration levels. Fresenius' Journal of Analytical Chemistry 351(6): 549-554, 1995

Non-monotonic concentration-response relationship of TiO(2) nanoparticles in freshwater cladocerans under environmentally relevant UV-A light. Ecotoxicology and Environmental Safety 101: 240-247, 2014

Behavioural and physiological responses of birds to environmentally relevant concentrations of an antidepressant. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 369(1656): -, 2015

Responses of Xanthoria parietina thalli to environmentally relevant concentrations of hexavalent chromium. Functional Plant Biology 31(4): 329-338, 2004

Physiological and growth responses of Thalassia testudinum to environmentally-relevant periods of low irradiance. Aquatic Botany 67(4): 287-300, August, 2000

Responses of laboratory exposed catfish (Clarias gariepinus) to environmentally relevant concentrations of p,p'-DDT. Environmental Toxicology and Pharmacology 34(3): 919-925, 2013

Genomic and proteomic responses to environmentally relevant exposures to dieldrin: indicators of neurodegeneration?. Toxicological Sciences 117(1): 190-199, 2010

Environmentally relevant xenoestrogen tissue concentrations correlated to biological responses in mice. Environmental Health Perspectives 108(10): 973-977, 2000