EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Tri-substituted phenyl derivatives and processes for their preparation



Tri-substituted phenyl derivatives and processes for their preparation



Official Gazette of the United States Patent & Trademark Office Patents 1235(3), June 20



Tri-substituted phenyl derivatives and processes for their preparation. In a preferred embodiment, the compounds have the general formula (1) ##STR1## wherein L may be --OR; Z may be --C(R3)(R4)--C(R5)(R6)(R7); R may be an optionally substituted cycloalkyl group; R3, R6 and R7 may be hydrogen; R4 may be --(CH2)t --Ar--(L1)n --Ar'; R5 may be --(CH2)t Ar; Ar may be a monocyclic or bicyclic aryl or heteroaryl group; L1 may be a divalent linking group; and Ar' is Ar or an Ar containing group. Compounds of the invention may be potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of various diseases, such as asthma, which are associated with an unwanted inflammatory response or muscular spasm.

(PDF 0-2 workdays service: $29.90)

Accession: 035985799

Download citation: RISBibTeXText



Related references

Tetra-substituted phenyl derivatives and processes for their preparation. Official Gazette of the United States Patent & Trademark Office Patents 1244(1), Mar 6, 2001

The synthesis of nitrofuran derivatives. 25. Preparation of alpha-(p-substituted phenyl)-5-nitro-2-furanacrylic acid, derivatives. Yakugaku Zasshi 81: 1512-1515, 1961

Studies on di phenyl methane derivatives part 3 synthesis of n substituted 1 2 3 di methoxyphenyl 1 2 3 or 4 substituted phenyl methylamine derivatives. Yakugaku Zasshi 95(1): 23-27, 1975

Studies on di phenyl methane derivatives part 2 synthesis of n substituted 1 3 4 di methoxyphenyl 1 2 3 or 4 substituted phenyl methylamine derivatives. Yakugaku Zasshi 95(1): 17-22, 1975

Substituted phenyl derivatives, their preparation and use. Official Gazette of the United States Patent & Trademark Office Patents 1280(3), Mar 16, 2004

Tri-substituted phenyl derivatives and processes for their preparations. Official Gazette of the United States Patent & Trademark Office Patents 1235(4), June 27, 2000

Substituted phenyl-piperazine derivatives, their preparation and use. Official Gazette of the United States Patent & Trademark Office Patents 1280(1), Mar 2, 2004

Use of substituted 1,2,4-oxadiazole derivatives for combating endoparasites, new substituted 1,2,4-oxadiazole derivatives, and processes for their preparation. Official Gazette of the United States Patent & Trademark Office Patents 1193(3): 2126, Dec 17, 1996

Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines and process for their preparation. Official Gazette of the United States Patent & Trademark Office Patents 1186(1): 445, May 7, 1996

Substituted phenyl-acyl-sulphon-amides and -cyanamides, processes for their preparation and their use in medicaments. Official Gazette of the United States Patent & Trademark Office Patents 1171(3): 1857-1858, Feb 21, 1995

Synthesis and in-vitro antifungal activity of 6-substituted-phenyl-2- {[(4'-substituted phenyl-5'-thioxo)-1,2,4-triazol-3-yl]-methyl}-2,3,4,5-tetrahydropyridazin-3-one derivatives. Acta Poloniae Pharmaceutica 65(2): 223-228, 2008

Phyto toxic activity of triazene derivatives part 3 1 phenyl 3 3 dialkyl triazenes variously bi substituted and tri substituted on the phenyl group. Farmaco Edizione Scientifica 29(2): 129-148, 1974

Design, Synthesis, and Biological Evaluation of 6-(2-Amino-substituted phenyl)-4-(substituted phenyl)-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Anticonvulsant Agents. Archiv der Pharmazie 349(4): 277-292, 2016

The biological activity of derivatives of 2-[(o-; and p-substituted)aminophenyl]-3H-5-[(o-; and p-substituted)phenyl]-7-chloro-1,4-benzodiazepines and 1-alkyl-3H-5-[(o-; and p- substituted) phenyl]-7-chloro-1,4-benzodiazepin-2-one. Proceedings of the Western Pharmacology Society 50: 87-92, 2008

Preparation of di phenyl indonyl substituted thio hydantoin derivatives of some amino acids. Dokladi na B"lgarskata Akademiya na Naukite 21(8): 785-788, 1968