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Vaccination with leishmanial antigen and CpG oligodeoxynucleotides confers long-term protection against Leishmania major infection

Vaccination with leishmanial antigen and CpG oligodeoxynucleotides confers long-term protection against Leishmania major infection

FASEB Journal 16(4): A307

ISSN/ISBN: 0892-6638

Vaccination of susceptible Balb/c mice with a plasmid DNA encoding a specific leishmanial antigen induced more durable immunity and effective control of infection compared to vaccination with leishmanial protein plus IL-12 protein. Mechanisms to explain these findings include the fact plasmid DNA vaccines contain immunostimulatory CpG motifs that have been shown to induce more durable Th1 responses in vivo when compared to IL-12 protein. Thus it was hypothesized that CpG ODN might induce more durable immunity and protection than IL-12 when used as a vaccine adjuvant with leishmanial protein. In these studies, using two different models of Leishmania major infection, susceptible Balb/c and resistant C57B1/6 mice were primed and boosted two weeks later with L. major protein with or without CpG ODN. Mice were then challenged either 2 or 12 weeks post-boost with L. major. In both models, mice vaccinated with leishmanial protein plus CpG ODN controlled infection when challenged 12 weeks post-boost. Current studies are evaluating the immune correlates of protection, focusing on the qualitative and quantitative aspects of Th1 responses and the role of CD8+ T cells.

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Accession: 036024548

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