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Vertebral artery dissection complicated by a thrombosis of the basilar artery was successfully treated with endovascular thrombolysis



Vertebral artery dissection complicated by a thrombosis of the basilar artery was successfully treated with endovascular thrombolysis



European Neurology 51(2): 110-113



Neovascularization in atherosclerotic plaques plays an essential role in the progression and rupture of plaques. Vascular endothelial growth factor (VEGF) is an important angiogenic factor. Echomorphologic evaluation of carotid plaques using computer-assisted imaging was found to have a good correlation with the histology of the lesion. The aim of this study was to investigate whether the serum VEGF level could be a determinant of the echomorphology of the carotid plaque. In 28 carotid plaques causing 60-99% stenosis, serum VEGF levels and the mean gray value (MGV) of three-dimensional image of the carotid plaques were measured. A statistically significant inverse correlation was found between serum VEGF concentrations and MGVs (Spearman's correlation coefficient: -0.415, p = 0.028). Our finding indicates that in patients with > or =60% carotid stenosis the serum VEGF levels are associated with the echogenicity of the atherosclerotic plaque.

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Accession: 036035582

Download citation: RISBibTeXText

PMID: 14963383

DOI: 10.1159/000076790


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