+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines



Probiotics and dietary counselling targeting maternal dietary fat intake modifies breast milk fatty acids and cytokines



European Journal of Nutrition 51(2): 211-219



Breast milk fatty acids possess immunomodulatory properties, and new intervention strategies beyond supplementation of maternal diet with single oils are called for. The objective of the present study was to evaluate the effect of dietary intervention during pregnancy and breastfeeding on breast milk fatty acid and cytokine composition. Pregnant women were randomised into three study groups: dietary intervention with probiotics (diet/probiotic) or with placebo (diet/placebo) and a control group (control/placebo). Dietary intervention included dietary counselling and provision of rapeseed oil-based food products. The probiotics used were Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 in combination. Dietary intake was evaluated by food records at every trimester of pregnancy and 1 month postpartum. Breast milk samples were collected after birth (colostrum) and 1 month after delivery for fatty acid and cytokine analysis (n = 125). Dietary intervention improved the quality of fat in the diet. In breast milk, the proportion of α-linolenic acid and total n-3 fatty acids was higher in both dietary intervention groups compared with control group (p < 0.05). In the diet/probiotic group, the γ-linolenic acid content was higher compared with the diet/placebo group (p < 0.05). The concentrations of TNF-α, IL-10, IL-4 and IL-2 were higher in both dietary intervention groups compared with controls, and furthermore, long-chain n-3 fatty acids were associated with several cytokines in colostrum samples. The present intervention demonstrated the possibility of modifying breast milk immunomodulatory factors by dietary means.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036111713

Download citation: RISBibTeXText

PMID: 21626296

DOI: 10.1007/s00394-011-0209-0


Related references

Maternal dietary intake of polyunsaturated fatty acids modifies the relationship between lead levels in bone and breast milk. Journal of Nutrition 138(1): 73-79, 2007

Maternal Dietary Intake of Polyunsaturated Fatty Acids Modifies the Relationship between Lead Levels in Bone and Breast Milk. The Journal of Nutrition 138(1): 73-79, 2008

The effect of a controlled manipulation of maternal dietary fat intake on medium and long chain fatty acids in human breast milk in Saskatoon, Canada. International Breastfeeding Journal 5: 3, 2010

Maternal intake of dietary virgin coconut oil modifies essential fatty acids and causes low body weight and spiky fur in mice. Bmc Complementary and Alternative Medicine 17(1): 79, 2017

Maternal dietary intake of polyunsaturated fatty acids modifies association between prenatal DDT exposure and child neurodevelopment: A cohort study. Environmental Pollution 238: 698-705, 2018

Maternal dietary intake of polyunsaturated fatty acids modifies association between prenatal DDT exposure and child neurodevelopment: A cohort study. Environmental Pollution 238: 698-705, 2018

Breast milk and adipose tissue fatty acid composition in relation to maternal dietary intake. Clinical Nutrition 2(2): 73-77, 1983

Fatty Acids Composition of Vegetable Oils and Its Contribution to Dietary Energy Intake and Dependence of Cardiovascular Mortality on Dietary Intake of Fatty Acids. International Journal of Molecular Sciences 16(6): 12871-12890, 2016

Maternal dietary Alpine butter intake affects human milk: fatty acids and conjugated linoleic acid isomers. Lipids 40(6): 581-587, 2005

Dietary patterns affect maternal macronutrient intake levels and the fatty acid profile of breast milk in lactating Chinese mothers. Nutrition 58: 83-88, 2018

Influences of maternal dietary intake and suckling on breast milk lipid and fatty acid composition in low-income women from Brasilia, Brazil. Early Human Development 81(3): 303-311, 2005

Cardiorespiratory fitness modifies the association between dietary fat intake and plasma fatty acids. European Journal of Clinical Nutrition 57(7): 810-815, 2003

Influence of maternal dietary n-3 fatty acids on breast milk and liver lipids of rat dams and offspring: A preliminary study. Nutrition Research 23(6): 747-760, 2003

Dietary interventions with n-3 fatty acids or probiotics targeting post-myocardial infarction depression. British Journal of Nutrition 109(1): 1-3, 2013

Dietary intake of n-3 PUFAs modifies the absorption, distribution and bioavailability of fatty acids in the mouse gastrointestinal tract. Lipids in Health and Disease 16(1): 10, 2017