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The localization and physiological effects of cannabinoid receptor 1 CB1 in the brain stem auditory system of the chick



The localization and physiological effects of cannabinoid receptor 1 CB1 in the brain stem auditory system of the chick







Fast, temporally-precise, and consistent synaptic transmission is required to encode features of acoustic stimuli. Neurons of nucleus magnocellularis (NM) in the auditory brain stem of the chick possess numerous adaptations to optimize the coding of temporal information. One potential problem for the system is the depression of synaptic transmission during a prolonged stimulus. The present studies tested the hypothesis that cannabinoid receptor one (CB1) signaling may limit synaptic depression at the auditory nerve-NM synapse. In situ hybridization was used to confirm that CB1 mRNA is expressed in the cochlear ganglion; immunohistochemistry was used to confirm the presence of CB1 protein.?We demonstrate the location and action of CB1 receptors in the avian cochlear nucleus. CB1 mRNA is expressed in the cochlear ganglion neurons. CB1 protein is located in the nucleus magnocellularis. CB1 agonist decreased EPSC amplitude and also reduced synaptic depression. Consistent activation could be important for coding prolonged acoustic stimuli.

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