+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Similarities in early course among men and women with a first episode of schizophrenia and schizophreniform disorder



Similarities in early course among men and women with a first episode of schizophrenia and schizophreniform disorder



European Archives of Psychiatry and Clinical Neuroscience 262(2): 95-105



The aims of this study were to analyze the presence of gender differences in the phenotypic expression of schizophrenia at the onset of illness and to explore whether these differences determine clinical and functional outcome 2 years after the initiation of treatment. Data from 231 first-episode-psychosis non-substance-dependent patients (156 men and 75 women) participating in a large-scale naturalistic open-label trial with risperidone were recorded at inclusion and months 1, 6, 12, and 24. Men presented a significant earlier age of onset (24.89 years vs. 29.01 years in women), poorer premorbid functioning, and a higher presence of prodromal and baseline negative symptoms. Women were more frequently married or lived with their partner and children and more frequently presented acute stress during the year previous to onset than men. No other significant clinical or functional differences were detected at baseline. The mean dose of antipsychotic treatment was similar for both genders during the study, and no significant differences in UKU scores were found. The number of hospitalizations was similar between groups, and adherence was more frequent among women. At the 2-year follow-up, both groups obtained significant improvements in outcome measures: PANSS, CGI severity, and GAF scores. Significant gender * time interactions were detected for negative and general PANSS subscales, with the improvement being more pronounced for men. However, no differences were detected for the mean scores obtained during the study in any outcome measure, and the final profile was similar for men and women. Our results suggest that although the initial presentation of schizophrenia can differ according to gender, these differences are not sufficient enough to determine differentiated outcome 2 years after the initiation of treatment in non-substance-dependent patients. The influence of gender on the early course of schizophrenia does not seem to be clinically or functionally decisive in this population.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036127055

Download citation: RISBibTeXText

PMID: 21614663

DOI: 10.1007/s00406-011-0218-2


Related references

Early insight predicts depression and attempted suicide after 4 years in first-episode schizophrenia and schizophreniform disorder. Acta Psychiatrica Scandinavica 112(6): 449-455, 2005

First-episode schizophreniform disorder: Comparisons with first-episode schizophrenia. Schizophrenia Research 46(1): 31-34, 30 November, 2000

A trial of low doses of risperidone in the treatment of patients with first-episode schizophrenia, schizophreniform disorder, or schizoaffective disorder. Journal of Clinical Psychopharmacology 24(2): 220-224, 2004

Predictors of noncompliance in males with first-episode schizophrenia, schizophreniform and schizoaffective disorder. European Psychiatry 17(3): 148-154, 2002

Depression during an acute episode of schizophrenia or schizophreniform disorder and its impact on treatment response. Psychiatry Research 158(3): 297-305, 2008

Can cerebral venticular enlargement predict progression of first-episode acute schizophreniform disorder in schizophrenia?. Schizophrenia Research 6(2): 150-151, 1992

Predictors of treatment discontinuation and medication nonadherence in patients recovering from a first episode of schizophrenia, schizophreniform disorder, or schizoaffective disorder: a randomized, double-blind, flexible-dose, multicenter study. Journal of Clinical Psychiatry 69(1): 106-113, 2008

Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial. Lancet 371(9618): 1085-1097, 2008

Improvement of psychiatric symptoms after electroconvulsive therapy in young adults with intractable first-episode schizophrenia and schizophreniform disorder. Tohoku Journal of Experimental Medicine 210(3): 213-220, 2006

Effectiveness of antipsychotics in first-episode schizophrenia and schizophreniform disorder on response and remission: an open randomized clinical trial (EUFEST). Schizophrenia Research 115(2-3): 97-103, 2009

Cognitive effects of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: a randomized, open-label clinical trial (EUFEST). American Journal of Psychiatry 166(6): 675-682, 2009

Cognitive Effects of Antipsychotic Drugs in First-Episode Schizophrenia and Schizophreniform Disorder: A Randomized, Open-Label Clinical Trial (EUFEST). Yearbook of Psychiatry and Applied Mental Health 2011: 298-300, 2011

Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study. Lancet. Psychiatry 5(10): 797-807, 2018

Early processing deficits in object working memory in first-episode schizophreniform psychosis and established schizophrenia. Psychological Medicine 35(7): 1053-1062, 2005

Spontaneous abnormal involuntary movements in first-episode schizophrenia and schizophreniform disorder: baseline rate in a group of patients from an Irish catchment area. American Journal of Psychiatry 155(9): 1202-1206, 1998