+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk

Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk

Oral Oncology 47(9): 866-872

The highest rates of oral squamous cell carcinomas are observed in south Asia, particularly in India, where complex forms of tobacco and alcohol exposures exist. Genetic polymorphisms contribute significantly to observed differences in cancer susceptibility. We examined the association of 13 variants in eight genes (rs4646903, rs2031920, rs3813867, GSTM1 null, GSTT1 null, rs1695, rs1138272, rs1799782, rs25487, rs1799791, rs1799793, rs13181 and rs1052133) involved in various stages of tobacco and alcohol metabolism and the risk of leukoplakia and oral cancer (OC) in a case-control study involving 219 oral leukoplakia, 665 OC and 802 age, sex and habit-matched controls. GSTT1 null and rs1695 were inversely associated with oral leukoplakia while GSTM1 null, GSTT1 null, rs2031920, rs3813867 (CYP2E1), and rs13181 were associated with OC. We report that genetic variants associated with premalignant and malignant conditions of the oral cavity differ. The associations appeared to be consistent among smokeless tobacco users, a characteristic risk factor in these parts.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 036144925

Download citation: RISBibTeXText

PMID: 21741876

DOI: 10.1016/j.oraloncology.2011.06.015

Related references

Polymorphisms at p53, p73, and MDM2 loci modulate the risk of tobacco associated leukoplakia and oral cancer. Molecular Carcinogenesis 48(9): 790-800, 2009

Do polymorphisms and haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer?. Mutation Research 648(1-2): 40-45, 2008

Do polymorphisms, haplotypes of mismatch repair genes modulate risk of sporadic colorectal cancer?. 2008

The cumulative effects of polymorphisms in the DNA mismatch repair genes and tobacco smoking in oesophageal cancer risk. Plos One 7(5): E36962, 2012

Single nucleotide polymorphisms in tobacco metabolism and DNA repair genes and prognosis in resected non-small-cell lung cancer. Journal of Surgical Research 167(1): E5-12, 2011

Polymorphisms in XRCC1, ERCC2, and ERCC3 DNA repair genes, CYP1A1 xenobiotic metabolism gene, and tobacco are associated with bladder cancer susceptibility in Tunisian population. Environmental Science and Pollution Research International 24(28): 22476-22484, 2017

Polymorphisms in DNA repair gene XPD, metabolism genes NAT1, NAT2, and GSTM1, smoking and bladder cancer risk. Proceedings of the American Association for Cancer Research Annual Meeting 42: 599-600, 2001

Relationship between polymorphisms of nucleotide excision repair genes and oral cancer risk in Taiwan: evidence for modification of smoking habit. Chinese Journal of Physiology 50(6): 294-300, 2008

Association of breast cancer risk with polymorphisms in genes involved in the metabolism of xenobiotics and interaction with tobacco smoking: a gene-set analysis. International Journal of Cancer 2018, 2018

Risk assessment of smokeless tobacco among oral precancer and cancer patients in eastern developmental region of Nepal. International Journal of Oral & Maxillofacial Surgery 44: E130-E131, 2015

Risk Assessment of Smokeless Tobacco among Oral Precancer and Cancer Patients in Eastern Developmental Region of Nepal. Asian Pacific Journal of Cancer Prevention 20(2): 411-415, 2019

Smoking and polymorphisms in xenobiotic metabolism and DNA repair genes are additive risk factors affecting bladder cancer in Northern Tunisia. Pathology Oncology Research 17(4): 879-886, 2012

Tobacco smoking, polymorphisms in carcinogen metabolism enzyme genes, and risk of localized and advanced prostate cancer: results from the California Collaborative Prostate Cancer Study. Cancer Medicine 3(6): 1644-1655, 2015

Comprehensive SNP scan of DNA repair and DNA damage response genes reveal multiple susceptibility loci conferring risk to tobacco associated leukoplakia and oral cancer. Plos One 8(2): E56952, 2013

Polymorphisms in DNA repair genes modulate survival in cisplatin/gemcitabine-treated non-small-cell lung cancer patients. Annals of Oncology 17(4): 668-675, 2006