We present results of our morphologic and stratigraphic investigations in the Amenthes region for which our observations suggest a complex spatial and temporal interrelation between volcanic and possibly water-related processes. We have produced a series of self-consistent geological maps and a stratigraphic correlation chart that show the spatial and temporal distribution of volcanic, fluvial and tectonic processes.The Amenthes region consists of a broad trough-like topographic depression that has served as a path for the supply of materials from Hesperia Planum to Isidis Planitia. It is most likely that Hesperia Planum and, in particular the area north of Hesperia Planum, including. Highlights: Amenthes Planum connects volcanic province of Hesperia Planum with Isidis Planitia. Amenthes Planum served as main path of transportation of fluvial/volcanic materials. Amenthes influenced by spatial/temporal interrelation of fluvial/volcanic processes. Formation of Tinto Vallis consistent with groundwater sapping/volcanic processes. Palos crater outflow channel bears striking evidence for catastrophic flood events. Tinto Vallis and Palos crater outflow channel formed later than dendritic valleys.