+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Interictal magnetoencephalographic findings related with surgical outcomes in lesional and nonlesional neocortical epilepsy



Interictal magnetoencephalographic findings related with surgical outcomes in lesional and nonlesional neocortical epilepsy



Seizure 20(9): 692-700



To investigate whether interictal magnetoencephalography (MEG) concordant with other techniques can predict surgical outcome in patients with lesional and nonlesional refractory neocortical epilepsy (NE). 23 Patients with lesional NE and 20 patients with nonlesional NE were studied. MEG was recorded for all patients with a 275 channel whole-head system. Synthetic aperture magnetometry (SAM) with excess kurtosis (g2) and conventional Equivalent Current Dipole (ECD) were used for MEG data analysis. 27 Patients underwent long-term extraoperative intracranial video electroencephalography (iVEEG) monitoring. Surgical outcomes were assessed based on more than 1-year of post-surgical follow-up using Engel classification system. As we expected, both favorable outcomes (Engel class I or II) and seizure freedom outcomes (Engel class IA) were higher for the concordance condition (MEG findings are concordant with MRI or iVEEG findings) versus the discordance condition. Also the seizure free rate was significantly higher (χ2=5.24, P<0.05) for the patients with lesional NE than for the patients with nonlesional NE. In 30% of the patients with nonlesional NE, the MEG findings proved to be valuable for intracranial electrode implantation. This study demonstrates that a favorable post-surgical outcome can be obtained in most patients with concordant MEG and MRI results even without extraoperative iVEEG monitoring, which indicates that the concordance among different modalities could indicate a likelihood of better postsurgical outcomes. However, extraoperative iVEEG monitoring remains prerequisite to the patients with discordant MEG and MRI findings. For nonlesional cases, our results showed that MEG could provide critical information in the placement of intracranial electrodes.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036157543

Download citation: RISBibTeXText

PMID: 21782477

DOI: 10.1016/j.seizure.2011.06.021


Related references

Ictal electrocorticographic findings related with surgical outcomes in nonlesional neocortical epilepsy. Epilepsy Research 48(3): 199-206, 2002

Magnetoencephalographic findings and seizure outcomes for neocortical epilepsy surgery. Epilepsia 45(Suppl 3): 177, 2004

Localization value of magnetoencephalography interictal spikes in adult nonlesional neocortical epilepsy. Journal of Korean Medical Science 27(11): 1391-1397, 2012

Outcomes following surgery for frontal lobe epilepsy Lesional vs nonlesional. Epilepsia 41(Suppl. 7): 149, 2000

Surgical approaches in nonlesional neocortical epilepsy. Journal of Epilepsy Research 1(2): 47-51, 2011

Surgical outcomes in lesional and non-lesional epilepsy: a systematic review and meta-analysis. Epilepsy Research 89(2-3): 310-318, 2010

Ictal EEG analysis recorded from subdural electrodes in relation to surgical outcome in nonlesional neocortical epilepsy. Epilepsia 41(Suppl. 7): 135, 2000

Pre-surgical evaluation and surgical outcome of 41 patients with non-lesional neocortical epilepsy. Seizure 11(3): 184-192, 2002

Poor surgical outcome in patients with neocortical epilepsy is correlated with interictal epileptiform abnormalities outside the area of surgical resection. Epilepsia 41(3): 355-357, 2000

Magnetoencephalography using total intravenous anesthesia in pediatric patients with intractable epilepsy: lesional vs nonlesional epilepsy. Brain & Development 31(1): 34-41, 2009

Re: Atypical language in lesional and nonlesional complex partial epilepsy. Neurology 70(23): 2266; Author Reply 2266-7, 2008

Atypical language in lesional and nonlesional complex partial epilepsy. Neurology 69(18): 1761-1771, 2007

Results of lesional vs. nonlesional frontal lobe epilepsy surgery. Stereotactic and Functional Neurosurgery 69(1-4 Pt 2): 202-209, 1997

Results of frontal lobe lesional and nonlesional epilepsy surgery. Epilepsia 37(Suppl. 5): 178, 1996

Intracranial electroencephalography seizure onset patterns and surgical outcomes in nonlesional extratemporal epilepsy. Journal of Neurosurgery 110(6): 1147-1152, 2009