+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

In vitro human skin permeation and cutaneous metabolism of catechins from green tea extract and green tea extract-loaded chitosan microparticles



In vitro human skin permeation and cutaneous metabolism of catechins from green tea extract and green tea extract-loaded chitosan microparticles



International Journal of Cosmetic Science 33(6): 572-579



Catechins are major antioxidants in green tea (Camellia sinensis or Camellia assamica), but because they do not permeate the skin well, the application of green tea in cosmetic products has so far been limited. This study aims to evaluate the cutaneous absorption of catechins from an extract of green tea and from a green tea extract-loaded chitosan microparticle. The catechin skin metabolism was also examined. The results suggest that chitosan microparticles significantly improve the ability of catechins to permeate skin. The cutaneous metabolism of the catechins significantly affected their permeation profiles. Epicatechin (EC) and epigallocatechin (EGC) penetrated the skin more than epigallocatechin gallate (EGCG) and epicatechin gallate (ECG). The galloyl groups in EGCG and ECG were enzymatically hydrolysed to EGC and EC, respectively. Dehydroxylation of catechins was also observed. Chitosan microparticles effectively prevented enzymatic changes of the catechins; therefore, chitosan microparticles are here found to be the promising carriers for enhancing the skin permeation.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036158744

Download citation: RISBibTeXText

PMID: 21790662

DOI: 10.1111/j.1468-2494.2011.00673.x


Related references

The inhibitory effect of green tea catechins and green tea extract on human liver sulfotransferase kinetics. Drug Metabolism Reviews 35(Suppl. 2): 198, 2003

Cytotoxicity induction by ethanolic extract of Acalypha indica loaded casein-chitosan microparticles in human prostate cancer cell line in vitro. Biomedicine & Preventive Nutrition, 2013

The comparison of effect of catechins and green tea extract on oxidative modification of LDL in vitro. Advances in Medical Sciences 51: 298-303, 2006

Tandem mass spectrometry studies of green tea catechins. Identification of three minor components in the polyphenolic extract of green tea. Journal of Mass Spectrometry 35(7): 860-869, 2000

Protein-reinforced and chitosan-pectin coated alginate microparticles for delivery of flavan-3-ol antioxidants and caffeine from green tea extract. Food Hydrocolloids 51: 361-374, 2015

Catechins play key role in green tea extract–induced postprandial hypoglycemic potential in vitro. European Food Research and Technology 237(2): 89-99, 2013

Effects of dietary grape seed extract, green tea extract, peanut extract and vitamin C supplementation on metabolism and survival of greenlip abalone (Haliotis laevigata Donovan) cultured at high temperature. Aquaculture 464: 364-373, 2016

Use of a content of catechins or a content of green tea extract in cosmetic preparations for tanning the skin. Official Gazette of the United States Patent & Trademark Office Patents 1259(1), 2002

Structural Features and the Anti-Inflammatory Effect of Green Tea Extract-Loaded Liquid Crystalline Systems Intended for Skin Delivery. Polymers 9(1):, 2017

Quantitative Analysis of Four Catechins from Green Tea Extract in Human Plasma Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Pharmacokinetic Studies. Molecules 23(4):, 2018

Pharmacokinetics of green tea catechins in extract and sustained-release preparations. Journal of Dietary Supplements 5(3): 248-263, 2008

Green tea extract and aged garlic extract inhibit anion transport and sickle cell dehydration in vitro. Blood Cells Molecules and Diseases 27(1): 148-157, 2001

Goitrogenic effects of green tea extract catechins by dietary administration in rats. Archives of Toxicology 75(10): 591-596, 2001

In Vitro Drug Metabolism of Green Tea Catechins in Human, Monkey, Dog, Rat and Mouse Hepatocytes. Drug Metabolism Letters 6(2): 73-93, 2012

Systemic Absorption of Catechins after Intraruminal or Intraduodenal Application of a Green Tea Extract in Cows. Plos one 11(7): E0159428, 2016