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Lactobacillus johnsonii HY742 ameliorates Gardnerella vaginalis-induced vaginosis by killing Gardnerella vaginalis and inhibiting NF-?B activation



Lactobacillus johnsonii HY742 ameliorates Gardnerella vaginalis-induced vaginosis by killing Gardnerella vaginalis and inhibiting NF-?B activation







Hydrogen peroxide-producing lactic acid bacteria (LAB) were isolated from women's vaginas and their anti-inflammatory effects against Gardnerella vaginalis-induced vaginosis were examined in ?-estradiol-immunosuppressed mice. Oral and intravaginal treatment with five LABs significantly decreased viable G. vaginalis numbers in vaginal cavities and myeloperoxidase activity in mouse vaginal tissues. Of the LABs examined, Lactobacillus johnsonii HY742 (LJ) most potently inhibited G. vaginalis-induced vaginosis. This LAB also inhibited the expressions of IL-1?, IL-6, TNF-?, COX-2, and iNOS, and the activation of NF-?B in vaginal tissues, but increased IL-1 expression. Orally administered LJ (.2 18CFU/mouse) also inhibited the expression of TNF-? by 91.7% in ?-estradiol-immunosuppressed.

Accession: 036162251

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