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Chromatin remodelling in mammalian cells by ISWI-type complexes--where, when and why?

Erdel, F.; Rippe, K.

FEBS journal 278(19): 3608-3618

2011


ISSN/ISBN: 1742-464X
PMID: 21810179
DOI: 10.1111/j.1742-4658.2011.08282.x
Accession: 036169059

The specific location of nucleosomes on the DNA has important inhibitory or activating roles in the regulation of DNA-dependent processes as it affects the DNA accessibility. It is dependent on the ATP-coupled activity of chromatin remodeling complexes that reposition nucleosomes or evict them from the DNA. The mammalian cell harbors numerous different remodeling complexes that possess distinct activities. These can translate a variety of signals into certain patterns of nucleosome positions with specific functions. Although chromatin remodelers have been extensively studied in vitro, much less is known about how they operate in their cellular environment. Here, we review cellular activities of the mammalian ISWI proteins, and discuss mechanisms by which they are targeted to sites where their activity is needed.

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