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The small GTPase BcCdc42 affects nuclear division, germination and virulence of the grey mould fungus Botrytis cinerea



The small GTPase BcCdc42 affects nuclear division, germination and virulence of the grey mould fungus Botrytis cinerea







The small GTPase Cdc42 plays a central role in various processes in eukaryotic cells including growth, differentiation and cytoskeleton organisation. Whereas it is essential in the yeast Saccharomyces cerevisiae, its role in filamentous fungi differs, due to the complementing, partly overlapping function of Rac. We analyzed the role of the Cdc42 homologue in the necrotrophic, broad host range pathogen Botrytis cinerea. Deletion mutants of bccdc42 showed various growth abnormalities; the mutants had reduced growth rate and hyphal branching, they produced fewer conidia, which were enlarged and misshapen and had germination defects. Additionally, the mutants were impaired in sclerotia development. Cytological. Highlights: Bccdc42, the cdc42 homologue of Botrytis cinerea, was functionally analysed. BcCdc42 has impact on form and germination of conidia and sclerotia formation. cdc42 mutants show disturbed nuclear division and migration in germ tubes. BcCdc42 is necessary for penetration and colonization of plant tissue.

Accession: 036170369

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