+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The pattern of cortical atrophy in Parkinson's disease with mild cognitive impairment according to the timing of cognitive dysfunction

The pattern of cortical atrophy in Parkinson's disease with mild cognitive impairment according to the timing of cognitive dysfunction

Journal of Neurology 259(3): 469-473

The density of Lewy bodies or the concurrent β-amyloid pathology would act as modulators in the relative timing of dementia during the course of Parkinson's disease. Depending on the temporal relationship between the onset of parkinsonism and that of cognitive impairment, patients with Parkinson's disease with mild cognitive impairment were divided into two groups of earlier (<1 year) and later (≥1 year) cognitive decline, and cortical atrophy patterns and correlation of gray matter and timing of cognitive decline were analyzed using voxel-based morphometry. The morphometric analysis showed that patients with earlier cognitive decline demonstrated greater cortical atrophy in the inferior parietal and orbitofrontal areas than did those with later cognitive decline. Additionally, the anatomical bases of the timing of their cognitive decline differed in terms of correlation patterns. These data suggest that the pathological burden in Parkinson's disease with mild cognitive impairment may be more severe in patients with earlier cognitive decline than in those with later cognitive decline, and that the neural basis corresponding to the timing of cognitive decline may differ in these patients.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 036172336

Download citation: RISBibTeXText

PMID: 21818688

DOI: 10.1007/s00415-011-6203-x

Related references

Mild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease. Neurobiology of Aging 78: 168-177, 2019

Olfaction and taste in Parkinson's disease: the association with mild cognitive impairment and the single cognitive domain dysfunction. Journal of Neural Transmission 126(5): 585-595, 2019

Subcortical atrophy is associated with cognitive impairment in mild Parkinson disease: a combined investigation of volumetric changes, cortical thickness, and vertex-based shape analysis. Ajnr. American Journal of Neuroradiology 35(12): 2257-2264, 2014

Visual Evaluation of Medial Temporal Lobe Atrophy as a Clinical Marker of Conversion from Mild Cognitive Impairment to Dementia and for Predicting Progression in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders 44(1-2): 12-24, 2017

Gender, apolipoprotein E genotype, and mesial temporal atrophy: 2-year follow-up in patients with stable mild cognitive impairment and with progression from mild cognitive impairment to Alzheimer's disease. Neuroradiology 58(11): 1143-1151, 2016

The difference of mild cognitive impairment in Parkinson's disease from amnestic mild cognitive impairment: Deeper power decrement and no phase-locking in visual event-related responses. International Journal of Psychophysiology 139: 48-58, 2019

Conscious attention defect and inhibitory control deficit in Parkinson's Disease-Mild Cognitive Impairment: A comparison study with Amnestic Mild Cognitive Impairment multiple domain. Psychiatria Danubina 29(4): 437-445, 2017

Frequency and Correlates of Subjective Memory Complaints in Parkinson's Disease with and without Mild Cognitive Impairment: Data from the Parkinson's Disease Cognitive Impairment Study. Journal of Alzheimer's Disease 63(3): 1015-1024, 2018

 Cortical Atrophy is Associated with Accelerated Cognitive Decline in Mild Cognitive Impairment with Subsyndromal Depression. American Journal of Geriatric Psychiatry 25(9): 980-991, 2017

Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment. Cerebral Cortex 26(6): 2411-2426, 2016

Gray matter atrophy associated with mild cognitive impairment in Parkinson's disease. Neuroscience Letters 617: 160-165, 2016

Cognitive profiles in Mild Cognitive Impairment (MCI) patients associated with Parkinson's disease and cognitive disorders. Annals of Indian Academy of Neurology 18(2): 200-205, 2015

Cortical thinning associated with mild cognitive impairment in Parkinson's disease. Movement Disorders 29(12): 1495-1503, 2014

Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment. Neurobiology of Aging 35(2): 291-300, 2014

Longitudinal assessment of mesial temporal lobe atrophy in elderly individuals with no cognitive impairment, mild cognitive impairment and alzheimers disease. Society for Neuroscience Abstract Viewer & Itinerary Planner : Abstract No 882 9, 2002