+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Epithelial barrier biology: good fences make good neighbours



Epithelial barrier biology: good fences make good neighbours



Immunology 135(1): 1-8



The external surfaces of the body, such as the skin and the gastrointestinal mucosal membrane, are an important line of defence preventing the invasion of microorganisms and their products. Mucosal immune cells, especially intraepithelial lymphocytes, are involved in maintaining the integrity of these epithelial barriers. They contribute towards the tolerance to commensal organisms, which occupy these same sites, and to the immune responses against harmful organisms and their products. The composition of the microbiota is influenced by immune cells as well as external environmental factors, especially the use of antibiotics and diet. There is an increasing appreciation that the microbiota affects systemic immune responses in addition to local immunity. Failure to control the occupancy by microorganisms may result in the disruption of the delicate homeostasis between beneficial and harmful microorganisms and contribute to inflammatory pathologies. This review will discuss some of our current understanding of the impact of immune cells and diet on the microbiota.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036194155

Download citation: RISBibTeXText

PMID: 22044254

DOI: 10.1111/j.1365-2567.2011.03506.x


Related references

Good fences make good neighbours: trespass at the urban fringe. Culture and Agriculture (30): 1-6, 1986

Territorial Borders, International Ethics and Geography: Do Good Fences Still Make Good Neighbours?. Geopolitics 8(2): 25-46, 2003

Good fences make good neighbours: the role of landmarks in territory partitioning in the rose bitterling (Rhodeus ocellatus). Behaviour 148(2): 233-246, 2011

Good fences make good neighbors: barrier elements and genomic regulation. Molecular Cell 16(4): 500-502, 2004

Are catenins and cadherins relevant to tumor biology? Good fences make good neighbors. Laboratory Investigation; a Journal of Technical Methods and Pathology 72(5): 491-493, 1995

Trenches like fences make good neighbours Revenue sharing around Kibale National Park, Uganda. Journal for Nature Conservation 20(2): 92-100, 2012

Good fences make good neighbors : cardiovascular science and medicine at the end of the millenium. Circulation 99(1): 6-7, 1999

Good Fences Make Good NeighborsBarrier Elements and Genomic Regulation. Molecular Cell 16(4): 500-502, 2004

Good fences make good neighbors: Gastrointestinal mucosal structure. Gut Microbes 1(1): 22-29, 2011

Good virtual fences make good neighbors: opportunities for conservation. Animal Conservation 17(3): 187-196, 2014

Good Fences Make Good Neighbors: A Response to Overton and Ennis. Human Development 49(3): 173-179, 2006

Good fences make for good neighbors but bad science: a review of what improves Bayesian reasoning and why. Frontiers in Psychology 6: 340, 2015

"Good Fences Make Good Neighbors": Geography as Self-Definition in Early Modern England. Isis 82(4): 639-661, 1991

Do Good Fences Make Good Neighbors? The Cross Border Impact of Casino Entrance. Growth and Change 45(1): 5-20, 2014

Brief: Software Licences: Good Fences Make Good Neighbors. Journal of Petroleum Technology 47(06): 506-507, 1995