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Neuropeptide levels in nasal secretions from patients with and without chronic cough

, : Neuropeptide levels in nasal secretions from patients with and without chronic cough. Annals of Allergy, Asthma & Immunology 107(4): 360-363

The pathophysiology of upper airway cough syndrome is not well understood. To investigate the levels of neuropeptides found in nasal mucus of subjects with and without the complaint of chronic cough. Preformed nasal mucus from 26 subjects complaining of postnasal drip with chronic cough and 17 without self-reported chronic cough was collected at the time of presentation. The nasal secretions were assayed for 3 neuropeptides substance P (SP), calcitonin gene-related peptide (CGRP), and Neurokinin A (NKA) that have been previously linked to chronic cough. Coughing subjects with postnasal drip have significantly higher levels of CGRP and SP than noncoughing subjects with postnasal drip (69. ng vs 4.6 ng,P< .1 and 4.5 ng vs 3.4 ng,P= .4). The differences in NKA levels in nasal secretions between coughing and noncoughing subjects did not reach statistical significance (16.3 ng vs 3.4 ng,P= .67). Both CGRP and SP levels are elevated in preformed nasal secretions of coughing subjects when compared with noncoughing subjects. Additional studies are needed to clarify whether CGRP and SP levels in preformed nasal secretions may assist in diagnosis or predicting treatment response in patients presenting with chronic cough.

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Accession: 036203184

PMID: 21962097

DOI: 10.1016/j.anai.2011.07.010

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Krastel Sebastian; Schmincke Hans Ulrich, 2001: Growth processes and destructive events during the evolution of the Canary Islands. Schriftenreihe der Deutschen Geologischen Gesellschaft 14: 113-114

Repo R., 1955: Stratigraphische Untersuchung ueber den bisher noerdlichsten rezenten Carex pseudocyperus- Fundort in Fennoskandien, den See Pitkaelampi in Liperi, Ostfinnland. A botanical and stratigraphic description (including diatom, pollen, and macrofossil analyses) is given of the northernmost present-day habitat of Carex pseudocyperus in Fennoscandia--in Liperi, eastern Finland. The properties of the habitat are r...

Goldstein, H., 1971: Factors influencing the height of seven year old children--results from the National Child Development Study. The height of all children born in Scotland, England and Wales between the 3rd and 9th March 1958, i.e., those in the National Child Development Study, was estimated when the children were between 7 and 8 years old. The variables considered were p...

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Everett, M. F.; Kulik, T. J.; Schumacher, R. E.; Becker, M. A.; Nicks, J. J.; Bandy, K. P., 1996: Do patient characteristics predict response to inhaled nitric oxide for neonatal persistent pulmonary hypertension?. Pediatric Research 39(4 PART 2): 331A

Riley, C. V., 1886: The Mulberry Silkworm; being a manual of instructions in Silk-culture. Sixth revised edition, with illustrations. The chief alteration in this edition appears to be a revision of the scale of profits that may be anticipated from silk-production in tho United States of North America.

O'boyle C.P.; Mcgarry K.; Fitzgerald D.; Kelly J.G.; Horgan J.; O'malley K., 1981: Clinical pharmacology of tolmesoxide in refractory heart failure. The hemodynamic effects and pharmacokinetics of single i.v. doses of tolmesoxide, a new vasodilator agent, were studied in 6 patients with severe cardiac failure secondary to ischemic cardiomyopathy and refractory to concentional therapy. The mean...

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