Section 37
Chapter 36,223

Xenotropic murine leukaemia virus-related virus is not found in peripheral blood cells from treatment-naive human immunodeficiency virus-positive patients

Maggi, F.; Focosi, D.; Lanini, L.; Sbranti, S.; Mazzetti, P.; Macera, L.; Davini, S.; De Donno, M.; Mariotti, M.L.; Antonelli, G.; Scatena, F.; Pistello, M.

Clinical Microbiology and Infection the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 18(2): 184-188


ISSN/ISBN: 1469-0691
PMID: 21672082
DOI: 10.1111/j.1469-0691.2011.03580.x
Accession: 036222323

Download citation:  

The human pathogen xenotropic murine leukaemia virus-related virus (XMRV) has been tentatively associated with prostate cancer and chronic fatigue syndrome. Unfortunately, subsequent studies failed to identify the virus in various clinical settings. To determine whether XMRV circulates in humans and the relationship with its host, we searched for the virus in 124 human immunodeficiency virus-infected patients who might have been exposed to XMRV, might be prone to infection as a result of progressive immunodeficiency, and had not yet been treated with antiretroviral drugs. Using nested PCR and single-step TaqMan real-time PCR, both designed on the XMRV gag gene, we could not find any positive samples. These findings add to the growing amount of scepticism regarding XMRV.

PDF emailed within 0-6 h: $19.90