+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Clinical outcomes and prognostic factors of Ewing sarcoma: a clinical analysis of 12 patients in Taiwan



Clinical outcomes and prognostic factors of Ewing sarcoma: a clinical analysis of 12 patients in Taiwan



Journal of the Chinese Medical Association 75(1): 16-20



Ewing sarcoma is extremely rare in people from East and Southeast Asia. The records of 12 patients diagnosed with primary Ewing sarcoma and treated at our institution from 1997 to 2009 were retrospectively reviewed. There were seven male and five female patients and their mean age at diagnosis was 22 years (range, 12-48 years). Two patients (16.7%) had distant metastasis at diagnosis. The primary tumor sites were the trunk in seven patients (58.3%) and the extremities in five patients (41.7%). Eleven patients received neoadjuvant chemotherapy followed by wide excision surgery, and then adjuvant chemotherapy. One patient received only chemotherapy without surgical intervention due to poor cardiac and pulmonary function. At a mean follow-up of 33 months, the 2-year overall survival rate (OS) was 45.5%. Distant metastasis was the only statistically significant prognostic factor of OS in our study. The 2-year OS rates of patients with lung metastasis and without lung metastasis were 0% and 42.9%, respectively (p = 0.021). The t(11;22)(q24:q12) translocation was present in all patients in our series. We confirmed that distant metastases is highly predictive of a poor outcome, and that the t(11;22)(q24:q12) translocation was present in all patients in our series.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036274184

Download citation: RISBibTeXText

PMID: 22240531

DOI: 10.1016/j.jcma.2011.10.013


Related references

Clinical outcomes and prognostic factors of adult's Ewing sarcoma family of tumors: single center experience. Contemporary Oncology 20(2): 141-146, 2016

Clinical Features and Prognostic Factors in Elderly Ewing Sarcoma Patients. Medical Science Monitor 24: 9370-9375, 2018

Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. Journal of Clinical Oncology 18(17): 3108-3114, 2000

The clinical use of biomarkers as prognostic factors in Ewing sarcoma. Clinical Sarcoma Research 2(1): 7, 2012

Prognostic factors and clinical outcome of patients with Ewing's sarcoma family of tumors in adults: multicentric study of the Anatolian Society of Medical Oncology. Medical Oncology 30(1): 469, 2013

Comparison of clinical features and outcomes in patients with extraskeletal vs skeletal Ewing sarcoma: an SEER database analysis of 3,178 cases. Cancer Management and Research 10: 6227-6236, 2018

Extraskeletal Ewing's sarcoma family of tumors in adults: prognostic factors and clinical outcome. Japanese Journal of Clinical Oncology 42(5): 420-426, 2012

An analysis of the prognostic factors affecing the clinical outcomes of conventional lumbar open discectomy : clinical and radiological prognostic factors. Asian Spine Journal 4(1): 23-31, 2010

Clinical features and outcomes in patients with secondary Ewing sarcoma. Pediatric Blood and Cancer 60(4): 611-615, 2013

Clinical features and outcomes in patients with extraskeletal Ewing sarcoma. Cancer 117(13): 3027-3032, 2011

Prognostic factors in the treatment of Ewing's sarcoma. The Ewing's Sarcoma Study Group of the German Society of Paediatric Oncology CESS 81. RadioTherapy and Oncology 10(2): 101-110, 1987

Non-metastatic Ewing's sarcoma family of tumors of bone in adolescents and adults: prognostic factors and clinical outcome-single institution results. Tumori 100(4): 452-458, 2014

Long-term follow-up and prognostic factors in Ewing's sarcoma. A multivariate analysis of 116 patients from a single institution. Oncology 55(1): 20-26, 1998

Multivariate analysis for clinical prognostic factors in 163 patients with soft tissue sarcoma. Cancer 62(7): 1444-1450, 1988

Clinical features and outcomes in patients with Ewing sarcoma and regional lymph node involvement. Pediatric Blood and Cancer 59(4): 617-620, 2012