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Antiviral resistance during the 29 influenza A H1N1 pandemic public health, laboratory, and clinical perspectives



Antiviral resistance during the 29 influenza A H1N1 pandemic public health, laboratory, and clinical perspectives







Influenza A H1N1 29 virus caused the first pandemic in an era when neuraminidase inhibitor antiviral drugs were available in many countries. The experiences of detecting and responding to resistance during the pandemic provided important lessons for public health, laboratory testing, and clinical management. We propose recommendations for antiviral susceptibility testing, reporting results, and management of patients infected with 29 pandemic influenza A H1NSustained global monitoring for antiviral resistance among circulating influenza viruses is crucial to inform public health and clinical recommendations for antiviral use, especially since community spread of oseltamivir-resistant A H1N1 29 virus remains a concern. Further studies are needed to better understand influenza management in specific patient groups, such as severely immunocompromised hosts, including optimisation of antiviral treatment, rapid sample testing, and timely reporting of susceptibility results.

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Accession: 036291003

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DOI: 10.1016/s1473-3099(11)70318-8


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