+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The dominance of human coronavirus OC43 and NL63 infections in infants

The dominance of human coronavirus OC43 and NL63 infections in infants

Journal of Clinical Virology 53(2): 135-139

It is unknown to what extent the human coronaviruses (HCoVs) OC43, HKU1, 229E and NL63 infect healthy children. Frequencies of infections are only known for hospitalized children. Comparing infection frequencies in children who have mild infections with frequencies in children needing hospital uptake will determine whether infection by one of the four HCoVs leads to more severe disease. In addition, the sequence of seroconversions can reveal whether infection by one HCoV protects from infection by other HCoVs. Two distinct study groups were monitored: healthy children and children hospitalized due to respiratory infection. HCoV natural infection rates in healthy children were obtained by serology in 25 newborns (followed 0-20months). The frequencies of severe HCoVs infection was determined by real time RT-PCR among 1471 hospitalized infants (<2-years old) with acute respiratory tract disease. The majority of healthy children seroconverted for HCoV-OC43 (n=19) and HCoV-NL63 (n=17), less for HCoV-HKU1 (n=9) and HCoV-229E (n=5). Notably, HCoV-HKU1 seroconversion was absent after HCoV-OC43 infection. Also HCoV-229E infection was rarely observed after HCoV-NL63 infection (1 out of 5). In the hospital 207 (14%) out of 1471 children were HCoV positive. Again we observed most infection by HCoV-OC43 (n=85) and HCoV-NL63 (n=60), followed by HCoV-HKU1 (n=47) and HCoV-229E (n=15). HCoV-NL63 and HCoV-OC43 infections occur frequently in early childhood, more often than HCoV-HKU1 or HCoV-229E infections. HCoV-OC43 and HCoV-NL63 may elicit immunity that protects from subsequent HCoV-HKU1 and HCoV-229E infection, respectively, which would explain why HCoV-OC43 and HCoV-NL63 are the most frequently infecting HCoVs. There are no indications that infection by one of the HCoVs is more pathogenic than others.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 036296773

Download citation: RISBibTeXText

PMID: 22188723

DOI: 10.1016/j.jcv.2011.11.011

Related references

Genetic variability of human coronavirus OC43-, 229E-, and NL63-like strains and their association with lower respiratory tract infections of hospitalized infants and immunocompromised patients. Journal of Medical Virology 78(7): 938-949, 2006

Characterization of human coronavirus OC43 and human coronavirus NL63 infections among hospitalized children <5 years of age. Pediatric Infectious Disease Journal 33(8): 814-820, 2015

Detection of human coronavirus NL63 and OC43 in children with acute respiratory infections in Niigata, Japan, between 2010 and 2011. Japanese Journal of Infectious Diseases 65(3): 270-272, 2012

Clinico-epidemiological characteristics of acute respiratory infections caused by coronavirus OC43, NL63 and 229E. Revista Clinica Espanola 214(9): 499-504, 2014

Human coronavirus NL63 infections in infants hospitalised with acute respiratory tract infections in South Africa. Influenza and other Respiratory Viruses 2(4): 135-138, 2008

Detection of the human coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata, Japan. Japanese Journal of Infectious Diseases 68(2): 138-141, 2015

Serological responses in patients with severe acute respiratory syndrome coronavirus infection and cross-reactivity with human coronaviruses 229E, OC43, and NL63. Clinical and Diagnostic Laboratory Immunology 12(11): 1317-1321, 2005

Comparative molecular epidemiology of two closely related coronaviruses, bovine coronavirus (BCoV) and human coronavirus OC43 (HCoV-OC43), reveals a different evolutionary pattern. Infection Genetics and Evolution 40: 186-191, 2016

Infections with human coronaviruses NL63 and OC43 among hospitalised and outpatient individuals in São Paulo, Brazil. Memorias do Instituto Oswaldo Cruz 107(5): 693-694, 2012

Infections with human coronaviruses Nl63 and Oc43 among hospitalised and outpatient individuals in So Paulo, Brazil. Memórias do Instituto Oswaldo Cruz 107(5): 693-694, 2012

Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China. Clinical Infectious Diseases 40(12): 1721-1729, 2005

Regulation of persistent infections with human coronavirus OC43. Advances in Experimental Medicine and Biology 218: 273-274, 1987

Coronavirus isolates SK and SD from multiple sclerosis patients are serologically related to murine coronaviruses A59 and JHM and human coronavirus OC43, but not to human coronavirus 229E. Journal of Virology 38(1): 231-238, 1981

Seroepidemiologic study of human coronavirus OC43 infections in Italy. Bollettino Dell'istituto Sieroterapico Milanese 57(4): 535-542, 1978

Severity and outcome associated with human coronavirus OC43 infections among children. Pediatric Infectious Disease Journal 32(4): 325-329, 2013