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Survival and complications following Gamma Knife radiosurgery or enucleation for ocular melanoma a 2-year experience

Survival and complications following Gamma Knife radiosurgery or enucleation for ocular melanoma a 2-year experience

We present our experience in treating ocular melanoma at the National Centre for Stereotactic Radiosurgery in Sheffield, UK over the last 2 years. Method We analysed 17 patients treated with Gamma Knife radiosurgery, recorded the evolution of visual acuity and complication rates, and compared their survival with 62 patients treated with eye enucleation. Different peripheral doses (using the 5% therapeutic isodose) were employed: 5-7 Gy for 24 patients, 45 Gy for 71 patients, 35 Gy for 62 patients. Findings There was no significant difference in survival between the 35-Gy, 45-Gy and 5 to 7-Gy groups when compared between themselves (p?=?.168) and with the enucleation group (p?=?.454). The 5-year survival rates were: 64% for 35 Gy, 62.71% for 45 Gy, 63.6% for 5 7 Gy and 65.2% for enucleated patients. Clinical variables influencing survival for radiosurgery patients were tumour volume (p?=?.14) and location (median 66.4 vs 37.36 months for juxtapapillary vs peripheral tumours, respectively; p?=?.1), while age and gender did not prove significant. Regarding complications, using 35 Gy led to more than a 5% decrease, when compared with the 45-Gy dose, in the incidence of cataract, glaucoma and retinal detachment. Retinopathy, optic neuropathy and vitreous haemorrhage were not significantly influenced. Blindness decreased dramatically from 83.7% for 45 Gy to 31.4% for 35 Gy (p?=?.6), as well as post-radiosurgery enucleation: 23.9% for 45 Gy vs 6.45% for 35 Gy (p?=?.18). Visual acuity, recorded up to 5 years post-radiosurgery, was significantly better preserved for 35 Gy than for 45 Gy (p?=?.3). Using 35 Gy led to a dramatic decrease in complications, vision loss and salvage enucleation, while not compromising patient survival.

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