+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Intraplatelet oxidative/nitrative stress: inductors, consequences, and control

Intraplatelet oxidative/nitrative stress: inductors, consequences, and control

Trends in Cardiovascular Medicine 20(7): 232-238

This article provides an overview of the current knowledge on intraplatelet oxidative/nitrative stress, an abnormality associated with platelet activation and hyper-reactivity. The first issue discussed is related to induction of platelet endogenous stress by the molecules present within the circulating (extracellular) milieu that bathes these cells. The second issue concerns the intraplatelet oxidative/nitrative stress associated with specific pathologies or clinical procedures and action of particular molecules and platelet agonists as well as of the specialized intraplatelet milieu and its redox system; the biomarkers of endogenous oxidative/nitrative stress are also briefly outlined. Next, the association between intraplatelet oxidative/nitrative stress and the risk factors of the metabolic syndrome is presented. Then, the most recent strategies aimed at the control/regulation of platelet endogenous oxidative/nitrative stress, such as exploitation of circulating extracellular reactive oxygen species scavengers, manipulation of platelet molecules, and the use of antioxidants, are discussed. Finally, the results of studies on platelet-dependent redox mechanisms, which deserve immediate attention for potential clinical exploitation, are illustrated.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 036324067

Download citation: RISBibTeXText

PMID: 22293024

DOI: 10.1016/j.tcm.2011.11.007

Related references

Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes 52(3): 818-823, 2003

Monitoring oxidative and nitrative modification of cellular proteins; a paradigm for identifying key disease related markers of oxidative stress. Advanced Drug Delivery Reviews 60(13-14): 1497-1503, 2008

A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging. Mechanisms of Ageing and Development 133(8): 523-529, 2013

Nitrative stress, oxidative stress and plasma endothelin levels after inhalation of particulate matter and ozone. Particle and Fibre Toxicology 12(): 28-28, 2016

Different vulnerability of fibrinogen subunits to oxidative/nitrative modifications induced by peroxynitrite: functional consequences. Thrombosis Research 121(2): 163-174, 2007

Oxidative and nitrative stress in neurodegeneration. Neurobiology of Disease 84: 4-21, 2016

Nitrative and oxidative stress in toxicology and disease. Toxicological Sciences 112(1): 4-16, 2010

Oxidative and nitrative stress markers in glaucoma. Free Radical Biology & Medicine 45(4): 367-376, 2008

Oxidative and nitrative stress in bronchial asthma. Antioxidants & Redox Signaling 10(4): 785-797, 2008

Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation. Biochemical Society Transactions 34(Pt 5): 965-970, 2006

Increase of MtNOS contributes to oxidative and nitrative stress in aging. 2007

Modulation of Hypercholesterolemia-Induced Oxidative/Nitrative Stress in the Heart. Oxidative Medicine and Cellular Longevity 2016: 3863726-3863726, 2016

Nonylphenol exposure is associated with oxidative and nitrative stress in pregnant women. Free Radical Research 49(12): 1469-1478, 2016

Nitration of Y10 in Aβ1-40: is it a compensatory reaction against oxidative/nitrative stress and Aβ aggregation?. Chemical Research in Toxicology 28(3): 401-407, 2015

Atmospheric pressure room temperature plasma jets facilitate oxidative and nitrative stress and lead to endoplasmic reticulum stress dependent apoptosis in HepG2 cells. Plos One 8(8): E73665-E73665, 2014