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Schizosaccharomyces pombehomologs of theSaccharomyces cerevisiaemitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis

, : Schizosaccharomyces pombehomologs of theSaccharomyces cerevisiaemitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis.

Complexes III and IV of the mitochondrial respiratory chain contain a few key subunits encoded by the mitochondrial genome. InSaccharomyces cerevisiae, fifteen mRNA-specific translational activators control mitochondrial translation, of which five are conserved inSchizosaccharomyces pombe. These include homologs of Cbp3, Cbp6 and Mss51 that participate in translation and the post-translational steps leading to the assembly of respiratory complexes III and IV. In this study we show that in contrast to budding yeast, Cbp3, Cbp6 and Mss51 fromS. pombeare not required for the translation of mitochondrial mRNAs, but fulfill post-translational functions, thus probably accounting for their conservation.S. cerevisiaecontains mRNA-specific activators controlling mitochondrial translation. Only a few of these factors seem conserved in the yeastS. pombeand in human. ConservedS. cerevisiaefactors have an additional complex assembly We find that the homologs inS. pombefulfil only this complex assembly function. The complex assembly function is thus probably the ancestral one..

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