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Living donor liver transplantation for autoimmune hepatitis and autoimmune hepatitis-primary biliary cirrhosis overlap syndrome



Living donor liver transplantation for autoimmune hepatitis and autoimmune hepatitis-primary biliary cirrhosis overlap syndrome







Recurrent autoimmune hepatitis (AIH) following liver transplantation has been reported in 2% to 3% of cases, mainly of Western populations. The aim of this study was to review our experience of living donor liver transplantation (LDLT) in Japanese patients with AIH. Among 375 adult (age >= 18 years) LDLTs performed at our center between 1996 and 21, 16 (4.2%) were for patients with AIH (n = 12) or AIH-primary biliary cirrhosis overlap syndrome (n = 4). The patient and donor characteristics and posttransplantation course were reviewed. All recipients were female with a median age of 48 (21-58) years. Low dose methylprednisolone and calcineurin inhibitors were continued in all patients. Acute cellular rejection occurred in 1 (63%), which was more frequent than in our overall series of 28.5% (17 of 375 cases). Overall survival rate was 81.2% at 5 years. At the end of the follow-up (median follow-up of 6. [ .1 9.6 ] years), 13 patients were alive with normal liver function tests; aspartate transaminase 18+-5 IU/ml and alanine transaminase 16+-8 IU/ml. None of the survivors exhibited liver function test results suspicious for recurrent AIH, which might indicate liver biopsy. Survival after LDLT for AIH and overlap syndrome was excellent and there was no evidence of clinical recurrence. The recurrence rate of AIH after liver transplantation may differ among countries, and requires further investigation.

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Accession: 036374379

Download citation: RISBibTeXText

PMID: 22548727

DOI: 10.1111/j.1872-034x.2012.01018.x


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