+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Imiquimod 5% Cream as Pre-Treatment of Mohs Micrographic Surgery for Nodular Basal Cell Carcinoma in the Face, A Prospective Randomized Controlled Study Imiquimod As Pre-Treatment of Mohs



Imiquimod 5% Cream as Pre-Treatment of Mohs Micrographic Surgery for Nodular Basal Cell Carcinoma in the Face, A Prospective Randomized Controlled Study Imiquimod As Pre-Treatment of Mohs







Imiquimod 5% cream can reduce or clear superficial and small nodular basal cell carcinoma (BCC). It could be used as a pre-treatment of Mohs micrographic surgery (MMS) to decrease defect size. To study if a pre-treatment with imiquimod 5% cream decreases defect size after Mohs micrographic surgery. In addition, to study the effect on the number of Mohs stages and reconstruction time. and Materials: Seventy patients >18 years with a primary nodular BCC in the face were included. The imiquimod group used imiquimod 5% cream for 4 weeks, before MMS. The control group was treated with MMS only.Tumour and defect sizes were measured. We noted the number of Mohs-stages, reconstruction time and side-effects. The median percentage increase in area from tumour size at baseline to the post-MMS defect for the imiquimod group was significantly less compared to the control group, 5% vs 147% (p=.). A tendency towards less Mohs stages in the imiquimod group was observed and the reconstruction time was significantly shorter in this group (.1) Imiquimod 5% cream as pre-treatment of MMS significantly reduced the tumour size in a primary nodular BCC and reduced the surgical defect size.Further research is necessary to investigate cost-effectiveness.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036392752

Download citation: RISBibTeXText

DOI: 10.1111/j.1365-2133.2012.10924.x


Related references

Imiquimod 5% cream as pretreatment of Mohs micrographic surgery for nodular basal cell carcinoma in the face: a prospective randomized controlled study. British Journal of Dermatology 167(1): 110-115, 2012

Imiquimod 5% Cream as Adjunctive Therapy for Primary, Solitary, Nodular Nasal Basal Cell Carcinomas Before Mohs Micrographic Surgery: A Randomized, Double Blind, Vehicle-Controlled Study. Yearbook of Dermatology and Dermatologic Surgery 2010: 348-349, 2010

Imiquimod 5% cream as adjunctive therapy for primary, solitary, nodular nasal basal cell carcinomas before Mohs micrographic surgery: a randomized, double blind, vehicle-controlled study. Dermatologic Surgery 35(1): 24-29, 2009

Imiquimod Cream and Reflectance-Mode Confocal Microscopy as Adjunct Modalities to Mohs Micrographic Surgery for Treatment of Basal Cell Carcinoma. Dermatologic Surgery 30(12, Part I): 1462-1469, 2004

5% imiquimod cream and reflectance-mode confocal microscopy as adjunct modalities to Mohs micrographic surgery for treatment of basal cell carcinoma. Dermatologic Surgery 30(12 Pt 1): 1462-1469, 2004

Confirmation of histological clearance of superficial basal cell carcinoma with multiple serial sectioning and Mohs' micrographic surgery following treatment with imiquimod 5% cream. Journal of Dermatological Treatment 19(3): 156-158, 2008

Imiquimod 5% Cream as Adjunctive Therapy For Primary, Solitary, Nodular Nasal Basal Cell Carcinomas Before Mohs Micrographic Surgery. Dermatologic Surgery 35(1): 24-29, 2009

Local immune modulator (imiquimod 5% cream) as adjuvant treatment after incomplete Mohs micrographic surgery for large, mixed type basal cell carcinoma: a report of 3 cases. Journal of Drugs in Dermatology 5(5): 461-464, 2006

Photodynamic Therapy Followed by Mohs Micrographic Surgery Compared to Mohs Micrographic Surgery Alone for the Treatment of Basal Cell Carcinoma: Results of a Pilot Single-Blinded Randomised Controlled Trial. Journal of Cutaneous and Aesthetic Surgery 8(2): 88-91, 2015

Imiquimod cream efficacy in the treatment of periocular nodular basal cell carcinoma: a non-randomized trial. Bmc Ophthalmology 15: 35, 2015

Surgical excision versus Mohs' micrographic surgery for primary and recurrent basal-cell carcinoma of the face: a prospective randomised controlled trial with 5-years' follow-up. Lancet. Oncology 9(12): 1149-1156, 2008

Mohs' micrographic surgery for treatment of basal cell carcinoma of the face--results of a retrospective study and review of the literature. British Journal of Dermatology 151(1): 141-147, 2004

Management of periocular basal cell carcinoma Mohs micrographic surgery versus radiotherapy I Mohs micrographic surgery. Survey of Ophthalmology 38(2): 193-203, 1993

Surgical excision vs Mohs' micrographic surgery for basal-cell carcinoma of the face: randomised controlled trial. Lancet 364(9447): 1766-1772, 2004

Imiquimod 5% cream for the treatment of superficial and nodular basal cell carcinoma: Randomized studies comparing low-frequency dosing with and without occlusion. British Journal of Dermatology 147(6): 1227-1236, 2002