+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Outcomes after liver transplantation for alcoholic hepatitis are similar to alcoholic cirrhosis: exploratory analysis from the UNOS database



Outcomes after liver transplantation for alcoholic hepatitis are similar to alcoholic cirrhosis: exploratory analysis from the UNOS database



Hepatology 55(5): 1398-1405



Data on liver transplantation for patients with alcoholic hepatitis are limited. Using the United Network for Organ Sharing database (2004-2010), adults undergoing liver transplantation for a listing diagnosis of alcoholic hepatitis were matched for age, gender, ethnicity, and model for endstage disease (MELD) score, donor risk index, and year of transplantation with three patients transplanted for a listing diagnosis of alcoholic cirrhosis. Study outcomes of graft and patient survival on follow-up were also analyzed for cohorts based on the diagnosis of the explant (46 alcoholic hepatitis and 138 alcoholic cirrhosis) and diagnosis at both listing as well as of the explant (11 alcoholic hepatitis and 33 alcoholic cirrhosis). Five-year graft and patient survival of alcoholic hepatitis and alcoholic cirrhosis patients were 75% and 73% (P = 0.97) and 80% and 78% (P = 0.90), respectively. Five-year graft and patient survival rates were also similar for cohorts based on diagnosis of the explant and diagnosis at listing as well as explant. Cox proportional regression analysis adjusting for other variables showed no impact of the etiology of liver disease (alcoholic hepatitis versus alcoholic cirrhosis) on the graft and patient survival. The causes of graft loss and patient mortality were similar in the two groups, and were not alcohol-related in any patient. Compared with alcoholic cirrhosis, patients with alcoholic hepatitis have similar posttransplantation graft and patient survival. Based on these preliminary findings, liver transplantation may be considered in a select group of patients with alcoholic hepatitis who fail to improve with medical therapy. Prospective studies are needed to assess the long-term outcome after liver transplantation in patients with alcoholic hepatitis.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036406488

Download citation: RISBibTeXText

PMID: 22213344

DOI: 10.1002/hep.25544


Related references

Mortality rate of alcoholic liver disease and risk of hospitalization for alcoholic liver cirrhosis, alcoholic hepatitis and alcoholic liver failure in Australia between 1993 and 2005. Internal Medicine Journal 41(1a): 34-41, 2011

Liver transplantation for alcoholic liver disease: Survival of patients transplanted with alcoholic hepatitis plus cirrhosis as compared with those with cirrhosis alone. Alcoholism Clinical and Experimental Research 17(5): 1102-1106, 1993

Alcoholic fatty liver, alcoholic hepatitis and alcoholic cirrhosis. Drinking behavior and incidence of clinical, clinico-chemical and histological findings in 282 patients. Deutsche Medizinische Wochenschrift 109(40): 1516-1521, 1984

The outcome of liver transplantation in adult patients with cryptogenic cirrhosis Comparison with primary biliary cirrhosis and autoimmune hepatitis using UNOS database. Hepatology. 36(4 Part 2): 666a, Ober, 2002

Improved survival outcomes in patients with non-alcoholic steatohepatitis and alcoholic liver disease following liver transplantation: an analysis of 2002-2012 United Network for Organ Sharing data. Clinical Transplantation 28(6): 713-721, 2015

Outcome after liver transplantation for cirrhosis due to alcohol and hepatitis C: comparison to alcoholic cirrhosis and hepatitis C cirrhosis. Journal of Clinical Gastroenterology 47(8): 727-733, 2013

Non-alcoholic fatty liver disease after orthotopic liver transplantation in patients with cryptogenic cirrhosis and non-alcoholic steatohepatitis. Gastroenterology 120(5 Suppl. 1): A 118, 2001

Consequences of severe alcoholic relapse after liver transplantation for alcoholic cirrhosis. Hepatology 34(4 Pt 2): 303A, 2001

Relationship between alcoholic relapse, non compliance and histological lesions after liver transplantation for alcoholic cirrhosis. Journal of Hepatology 36(Suppl. 1): 38, 2002

Lymphocyte markers in the liver in alcoholic hepatitis and alcoholic cirrhosis. Journal of Hepatology 34(Suppl. 1): 202, 2001

Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and/or hepatitis C virus cirrhosis: a prospective follow up study. Gut 46(2): 277-282, 2000

Association between HLA-B40 and acute alcoholic hepatitis with cirrhosis and the lack of relation between carcinoembryonic antigen and HLA antigens in alcoholic liver disease. Scandinavian Journal of Gastroenterology 18(2): 267-271, 1983

Alcoholic recidivism after liver transplantation for alcoholic cirrhosis. Journal of Clinical Gastroenterology 26(3): 204-206, 1998

Outcomes After Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis: Additional Evidence From a Meta-analysis. Gastroenterology 156(1): 285-286, 2019

Rapidly progressive liver injury and fatal alcoholic hepatitis occurring after liver transplantation in alcoholic patients. Transplantation 67(12): 1562-1568, 1999