EurekaMag
+ Translate
+ Most Popular
The pigeon tick (Argas reflexus): its biology, ecology, and epidemiological aspects
Prevalence of hemoglobin abnormalities in Kebili (Tunisian South)
Lipogranuloma: a preventable complication of dacryocystorhinostomy
Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency
Bees from the Belgian Congo. The acraensis group of Anthophora
Placing gingival retraction cord
Total serum IgE, allergy skin testing, and the radioallergosorbent test for the diagnosis of allergy in asthmatic children
Acariens plumicoles Analgesoidea parasites des oiseaux du Maroc
Injuries of terminal phalanges of the fingers in children
Biology of flowering and nectar production in pear (Pyrus communis)
Das Reliktvorkommen der Aspisviper (Vipera aspis L.) im Schwarzwald
Hydrological modelling of drained blanket peatland
Pathologic morphology and clinical significance of the anomalous origin of the left circumflex coronary artery from the right coronary artery. General review and autopsy analysis of 30 cases
Cyto genetic analyses of lymphocyte cultures after exposure to calcium cyclamate
Axelrodia riesei, a new characoid fish from Upper Rio Meta in Colombia With remarks concerning the genus Axelrodia and description of a similar, sympatric, Hyphessobrycon-species
Favorable evolution of a case of tuberculosis of pancreas under antibiotic action
RIFM fragrance ingredient safety assessment, Valencene, CAS Registry Number 4630-07-3
Parenteral microemulsions: an overview
Temperate pasture: management for grazing and conservation
Evaluation of a new coprocessed compound based on lactose and maize starch for tablet formulation
Thermal expansion and cracking of three confined water-saturated igneous rocks to 800C
Revision of the genera of the tribe Stigmoderini (Coleoptera: Buprestidae) a discussion of phylogenetic relationships
Anal tuberculosis. Report of a case
Gastric tuberculosis in the past and present
Adaptive responses of the cardiovascular system to prolonged spaceflight conditions: assessment with Holter monitoring

Following Ariadne's thread: a new perspective on RBR ubiquitin ligases


Following Ariadne's thread: a new perspective on RBR ubiquitin ligases



Bmc Biology 10: 24



ISSN/ISBN: 1741-7007

PMID: 22420831

DOI: 10.1186/1741-7007-10-24

Ubiquitin signaling pathways rely on E3 ligases for effecting the final transfer of ubiquitin from E2 ubiquitin conjugating enzymes to a protein target. Here we re-evaluate the hybrid RING/HECT mechanism used by the E3 family RING-between-RINGs (RBRs) to transfer ubiquitin to substrates. We place RBRs into the context of current knowledge of HECT and RING E3s. Although not as abundant as the other types of E3s (there are only slightly more than a dozen RBR E3s in the human genome), RBRs are conserved in all eukaryotes and play important roles in biology. Re-evaluation of RBR ligases as RING/HECT E3s provokes new questions and challenges the field.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036419314

Download citation: RISBibTeXText

Related references

Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling. Journal of Biological Chemistry 294(8): 2651-2664, 2019

Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. Journal of Biological Chemistry 282(24): 17375-17386, 2007

Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. Journal of Biological Chemistry 276(22): 19640-19647, 2001

In search of Ariadne's thread. Psychiatria Polska 36(5): 685-693, 2002

The Ariadne's thread of tetrapods. La Recherche 1(7): 686-687, 1970

Ariadne's thread NMR challenge. Analytical and Bioanalytical Chemistry 406(27): 6757-6761, 2014

Klagt Ariadne? Überlegungen zur Rede der Ariadne in Catulls carmen 64 - Does Ariadne complain? Reflections about Ariadne's speech in Catullus' «Carmen 64» - Les plaintes d'Ariane? Réflexions sur le monologue d'Ariane dans le «Chant 64» de Catulle. Gymnasium (Heidelberg) 109(2): 91-102, 2002

Following the thread of Ariadne to the health of women. Health Care for Women International 17(3): 201-208, 1996

Solution to the Ariadne's thread NMR challenge. Analytical and Bioanalytical Chemistry 407(7): 1793-1794, 2015

This Ariadne's thread saved another life!. Gastrointestinal Endoscopy 81(4): 1029; Discussion 1029-30, 2015

Viroids: an Ariadne's thread into the RNA labyrinth. Embo Reports 7(6): 593-598, 2006

The Ariadne's Thread of The Red Book. Jung Journal 9(1): 68-72, 2015

Medical documentation: from the labyrinth to Ariadne's thread. Bruxelles Medical 58(4): 229-231, 1978

H2AX and lung cancer: is it the Ariadne's thread?. Dna Repair 12(2): 90-91, 2013

Ecological immunity of arthropods - a thread of Ariadne?. Trends in Ecology and Evolution 17(5): 204-205, 2002