+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Second trimester estimated fetal weight and fetal weight gain predict childhood obesity

Second trimester estimated fetal weight and fetal weight gain predict childhood obesity

Journal of Pediatrics 161(5): 864-870

To determine the extent to which fetal weight during mid-pregnancy and fetal weight gain from mid-pregnancy to birth predict adiposity and blood pressure (BP) at age 3 years. Among 438 children in the Project Viva cohort, we estimated fetal weight at 16-20 (median 18) weeks' gestation using ultrasound biometry measures. We analyzed fetal weight gain as change in quartile of weight from the second trimester until birth, and we measured height, weight, subscapular and triceps skinfold thicknesses, and BP at age 3. Mean (SD) estimated weight at 16-20 weeks was 234 (30) g and birth weight was 3518 (420) g. In adjusted models, weight estimated during the second trimester and at birth were associated with higher body mass index (BMI) z-scores at age 3 years (0.32 unit [95% CI, 0.04-0.60 unit] and 0.53 unit [95% CI, 0.24-0.81 unit] for the highest vs lowest quartile of weight). Infants with more rapid fetal weight gain and those who remained large from mid-pregnancy to birth had higher BMI z-scores (0.85 unit [95% CI, 0.30-1.39 unit] and 0.63 unit [95% CI, 0.17-1.09 unit], respectively) at age 3 than did infants who remained small during fetal life. We did not find associations between our main predictors and sum or ratio of subscapular and triceps skinfold thicknesses or systolic BP. More rapid fetal weight gain and persistently high fetal weight during the second half of gestation predicted higher BMI z-score at age 3 years. The rate of fetal weight gain throughout pregnancy may be important for future risk of adiposity in childhood.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 036443095

Download citation: RISBibTeXText

PMID: 22682615

DOI: 10.1016/j.jpeds.2012.04.065

Related references

Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood. American Journal of Obstetrics and Gynecology 212(4): 502.E1-14, 2015

OP27.01: Third trimester fetal arm and thigh fat mass: their relationship to estimated fetal weight, birth weight and neonatal body composition. Ultrasound in Obstetrics & Gynecology 34(S1): 149-149, 2009

Third trimester abdominal circumference alone is comparable to estimated fetal weight to predict small for gestational age at birth: a meta-analysis. American Journal of Obstetrics and Gynecology 216(1): S151-S152, 2017

Prediction of fetal growth restriction using estimated fetal weight vs a combined screening model in the third trimester. Ultrasound in Obstetrics and Gynecology 50(5): 603-611, 2016

Second-trimester estimated fetal weight and discordance in twin pregnancies: association with fetal growth restriction. Journal of Ultrasound in Medicine 30(8): 1095-1101, 2011

Development of individual growth standards for estimated fetal weight: II. Weight prediction during the third trimester and at birth. Journal of Clinical Ultrasound 17(2): 83-88, 1989

Combined Influence of Gestational Weight Gain and Estimated Fetal Weight on Risk Assessment for Small- or Large-for-Gestational-Age Birth Weight: A Prospective Cohort Study. Journal of Ultrasound in Medicine 37(4): 935-940, 2017

Weight and weight gain during early infancy predict childhood obesity a case-cohort study. International Journal of Obesity 36(10): 1306-1311, 2012

Three models for defining third trimester fetal weight gain. American Journal of Obstetrics & Gynecology 180(1 PART 2): S67, 1999

The association between second trimester estimated fetal weight and small for gestational age at birth. Journal of Maternal-Fetal and Neonatal Medicine 29(15): 2398-2402, 2017

Maternal weight gain: a determinant for fetal abdominal circumference in the second trimester. Acta Obstetricia et Gynecologica Scandinavica 90(6): 666-670, 2011

Association of second and third trimester weight gain in pregnancy with maternal and fetal outcomes. Plos One 8(1): E54704, 2013

Correlation of 2nd trimester amniotic fluid amino acid profile with gestational age and estimated fetal weight. Journal of Maternal-Fetal and Neonatal Medicine 24(8): 1033-1038, 2012

Is maternal weight gain during pregnancy associated with fetal growth patterns between the 2nd and 3rd trimester as determined by ultrasound?. American Journal of Obstetrics and Gynecology 216(1): S71-S72, 2017

Does gestational weight gain in normal pre-pregnancy BMI pregnant women reflect fetal weight gain?. Journal of the Medical Association of Thailand 95(7): 853-858, 2012