EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Measles vaccine expressing the secreted form of West Nile virus envelope glycoprotein induces protective immunity in squirrel monkeys, a new model of West Nile virus infection


Measles vaccine expressing the secreted form of West Nile virus envelope glycoprotein induces protective immunity in squirrel monkeys, a new model of West Nile virus infection



Journal of Infectious Diseases 206(2): 212-219



ISSN/ISBN: 0022-1899

PMID: 22551814

DOI: 10.1093/infdis/jis328

West Nile virus (WNV) is a mosquito-borne flavivirus that emerged in North America and caused numerous cases of human encephalitis, thus urging the development of a vaccine. We previously demonstrated the efficacy of a recombinant measles vaccine (MV) expressing the secreted form of the envelope glycoprotein from WNV to prevent WNV encephalitis in mice. In the present study, we investigated the capacity of this vaccine candidate to control WNV infection in a primate model. We first established experimental WNV infection of squirrel monkeys (Saimiri sciureus). A high titer of virus was detected in plasma on day 2 after infection, and viremia persisted for 5 days. A single immunization of recombinant MV-WNV vaccine elicited anti-WNV neutralizing antibodies that strongly reduced WNV viremia at challenge. This study demonstrates for the first time the capacity of a recombinant live attenuated measles vector to protect nonhuman primates from a heterologous infectious challenge.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 036461388

Download citation: RISBibTeXText

Related references

Live measles vaccine expressing the secreted form of the West Nile virus envelope glycoprotein protects against West Nile virus encephalitis. Journal of Infectious Diseases 191(2): 207-214, 2004

Live measles vaccine expressing the secreted form of the west nile virus envelope glycoprotein protects against west nile virus encephalitis. The Journal of Infectious Diseases 191(2): 207-214, 2005

Live measles vaccine expressing the secreted form of the West Nile virus envelope glycoprotein protects against West Nile virus encephalitis. Virologie 9(1): 69-70, 2005

A recombinant influenza a virus expressing domain IIi of West Nile virus induces protective immune responses against influenza and West Nile virus. Plos one 6(4): E18995, 2011

Duration of immunity against experimentally induced West Nile virus encephalomyelitis in horses using a West Nile virus chimera vaccine. Proceedings of the 52nd Annual Convention of the American Association of Equine Practitioners, San Antonio, Texas, USA, 2-6 December 2006: 235-236, 2006

Infection with non-lethal West Nile virus Eg101 strain induces immunity that protects mice against the lethal West Nile virus NY99 strain. Viruses 6(6): 2328-2339, 2014

Immunization of flavivirus West Nile recombinant envelope domain III protein induced specific immune response and protection against West Nile virus infection. Journal of Immunology 178(5): 2699-2705, 2007

Vero cell-derived inactivated West Nile (WN) vaccine induces protective immunity against lethal WN virus infection in mice and shows a facilitated neutralizing antibody response in mice previously immunized with Japanese encephalitis vaccine. Virology 374(1): 60-70, 2008

Molecularly engineered live-attenuated chimeric West Nile/dengue virus vaccines protect rhesus monkeys from West Nile virus. Virology 314(1): 190-195, 2003

Modulation of innate immune signaling by the secreted form of the West Nile virus NS1 glycoprotein. Virology 458-459: 172-182, 2014

Influence of Demography, Land Use, and Urban Form on West Nile Virus Risk and Human West Nile Virus Incidence in Ottawa, Canada. Vector Borne and Zoonotic Diseases 19(7): 533-539, 2019

Safety and efficacy of a live attenuated West Nile virus chimera vaccine in horses with experimentally induced West Nile virus clinical disease. Proceedings of the 51st Annual Convention of the American Association of Equine Practitioners, Seattle, Washington, USA, 3-7 December 2005: 177-179, 2005

Assessment of the efficacy of a single dose of a recombinant vaccine against West Nile virus in response to natural challenge with West Nile virus-infected mosquitoes in horses. American Journal of Veterinary Research 65(11): 1459-1462, 2004

Evaluation of the efficacy provided by a Recombinant Canarypox-Vectored Equine West Nile Virus vaccine against an experimental West Nile Virus intrathecal challenge in horses. Veterinary Therapeutics: Research in Applied Veterinary Medicine 7(3): 249-256, 2006

Recombinant canarypoxvirus vaccine carrying the prM/E genes of West Nile virus protects horses against a West Nile virus-mosquito challenge. Archives of Virology. Supplementum 2004(18): 221-230, 2004