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Dietary selenium fortification a potential solution to chronic arsenic toxicity



Dietary selenium fortification a potential solution to chronic arsenic toxicity



Toxicological & Environmental Chemistry 94(7): 1453-1465



Selenium (Se), an important micronutrient and antioxidant, also acts as an antagonist of arsenic (As). Se supplementation of diet was investigated in mitigating chronic As toxicity in mammals. Experiments were conducted to determine whether Se supplementation in As-exposed rats might (i) decrease As-induced lipid peroxidation in liver, (ii) increase blood antioxidant status, and (iii) reverse suppression of the secondary antibody response. Male Wistar rats were exposed to As (4 and 8?ppm) in drinking water and received challenge diets with three different levels of Se (deficient: <.1?ppm, adequate: .15 ppm, and fortified: .6?ppm) for 16 weeks. Clinical variables including behavior, body weight, and food and water consumption were recorded weekly, and blood sample was collected monthly. Antioxidant status was assessed through glutathione sulfhydryl (GSH) levels in whole blood. Lipid peroxidation in the liver was evaluated using the malondialdehyde (MDA) assay. The antibody response was measured using.

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Accession: 036483720

Download citation: RISBibTeXText

DOI: 10.1080/02772248.2012.701104


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