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DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic



DALI: Defining Antibiotic Levels in Intensive care unit patients: a multi-centre point of prevalence study to determine whether contemporary antibiotic dosing for critically ill patients is therapeutic



Bmc Infectious Diseases 12: 152-152



The clinical effects of varying pharmacokinetic exposures of antibiotics (antibacterials andantifungals) on outcome in infected critically ill patients are poorly described. A large-scalemulti-centre study (DALI Study) is currently underway describing the clinical outcomes ofpatients achieving pre-defined antibiotic exposures. This report describes the protocol. DALI will recruit over 5 patients administered a wide range of either beta-lactam orglycopeptide antibiotics or triazole or echinocandin antifungals in a pharmacokinetic pointprevalencestudy. It is anticipated that over 7 European intensive care units (ICUs) willparticipate. The primary aim will be to determine whether contemporary antibiotic dosing forcritically ill patients achieves plasma concentrations associated with maximal activity.Secondary aims will compare antibiotic pharmacokinetic exposures with patient outcome andwill describe the population pharmacokinetics of the antibiotics included. Various subgroupanalyses will be conducted to determine patient groups that may be at risk of very low or veryhigh concentrations of antibiotics.DiscussionThe DALI study should inform clinicians of the potential clinical advantages of achievingcertain antibiotic pharmacokinetic exposures in infected critically ill patients.

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Accession: 036485622

Download citation: RISBibTeXText

PMID: 22768873

DOI: 10.1186/1471-2334-12-152



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